Literature DB >> 9762364

Cobalamin-dependent methionine synthase and serine hydroxymethyltransferase: targets for chemotherapeutic intervention?

R G Matthews1, J T Drummond, H K Webb.   

Abstract

Chemotherapeutic drugs targeted at folate-dependent reactions have typically been directed at a limited number of target enzymes: dihydrofolate reductase, thymidylate synthase, and GAR and AICAR transformylase. This review discusses two other potential targets for chemotherapeutic inhibition: cobalamin-dependent methionine synthase and serine hydroxymethyltransferase. Brief reviews of the catalytic properties of these two enzymes are presented, and possible strategies for chemotherapeutic intervention are discussed.

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Year:  1998        PMID： 9762364     DOI： 10.1016/s0065-2571(97)00006-x

Source DB:  PubMed          Journal:  Adv Enzyme Regul        ISSN： 0065-2571


  6 in total

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Review 2.  Targeting purine and pyrimidine metabolism in human apicomplexan parasites.

Authors:  John E Hyde
Journal:  Curr Drug Targets       Date:  2007-01       Impact factor: 3.465

3.  Enolases: storage compounds in seeds? Evidence from a proteomic comparison of zygotic and somatic embryos of Cyclamen persicum Mill.

Authors:  Christina Rode; Sébastien Gallien; Dimitri Heintz; Alain Van Dorsselaer; Hans-Peter Braun; Traud Winkelmann
Journal:  Plant Mol Biol       Date:  2011-01-20       Impact factor: 4.076

4.  Overexpression and characterization of dimeric and tetrameric forms of recombinant serine hydroxymethyltransferase from Bacillus stearothermophilus.

Authors:  Venkatakrishna R Jala; V Prakash; N Appaji Rao; H S Savithri
Journal:  J Biosci       Date:  2002-06       Impact factor: 1.826

5.  MetR-regulated Vibrio cholerae metabolism is required for virulence.

Authors:  Ryan W Bogard; Bryan W Davies; John J Mekalanos
Journal:  MBio       Date:  2012-09-25       Impact factor: 7.867

6.  Methionine synthase supports tumour tetrahydrofolate pools.

Authors:  Jonathan M Ghergurovich; Xincheng Xu; Joshua Z Wang; Lifeng Yang; Rolf-Peter Ryseck; Lin Wang; Joshua D Rabinowitz
Journal:  Nat Metab       Date:  2021-11-18
  6 in total

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