Literature DB >> 9760132

Medial nigral dopamine neurons have rich neurotrophin support in humans.

T Nishio1, S Furukawa, I Akiguchi, N Sunohara.   

Abstract

To assess the action of neurotrophin in human dopaminergic neurons, we studied the immunolocalization of neurotrophins or trks in human substantia nigra pars compacta (SNc). The neuromelanin-containing neurons in the SNc showed immunoreactivities for neurotrophins or trks, suggesting an autocrine/paracrine regulation. Quantitative analysis revealed that the percentage of those expressing NGF-like immunoreactivity (NGF-LI), BDNF-LI, NT3-LI, trkA-LI, trkB-LI, or trkC-LI was 66%, 74%, 85%, 66%, 71% or 86%, respectively. The percentage of cells expressing neurotrophins or trks was higher in the medial part than in the lateral part of the SNc. The preferential expression of neurotrophin-trk systems in the medial neurons may, at least partially, explain the differential susceptibility in Parkinson's disease.

Entities:  

Mesh：

Substances：

Year:  1998        PMID： 9760132     DOI： 10.1097/00001756-199808240-00030

Source DB:  PubMed          Journal:  Neuroreport        ISSN： 0959-4965            Impact factor:   1.837


  10 in total

1.  Neurotrophin receptor heterozygosity causes deficits in catecholaminergic innervation of amygdala and hippocampus in aged mice.

Authors:  O von Bohlen Und Halbach; L Minichiello
Journal:  J Neural Transm (Vienna)       Date:  2006-06-01       Impact factor: 3.575

2.  The TrkB-positive dopaminergic neurons are less sensitive to MPTP insult in the substantia nigra of adult C57/BL mice.

Authors:  Yin-Xiu Ding; Yi Xia; Xi-Ying Jiao; Li Duan; Jun Yu; Xi Wang; Liang-Wei Chen
Journal:  Neurochem Res       Date:  2011-05-12       Impact factor: 3.996

3.  BDNF Val66Met polymorphism and antipsychotic-induced tardive dyskinesia occurrence and severity: a meta-analysis.

Authors:  Itaru Miura; Jian-Ping Zhang; Masahiro Nitta; Todd Lencz; John M Kane; Anil K Malhotra; Hirooki Yabe; Christoph U Correll
Journal:  Schizophr Res       Date:  2014-01-07       Impact factor: 4.939

4.  Brain-derived neurotrophic factor is required for the establishment of the proper number of dopaminergic neurons in the substantia nigra pars compacta.

Authors:  Zachary C Baquet; Paula C Bickford; Kevin R Jones
Journal:  J Neurosci       Date:  2005-06-29       Impact factor: 6.167

5.  Altered BDNF is correlated to cognition impairment in schizophrenia patients with tardive dyskinesia.

Authors:  Jing Qin Wu; Da Chun Chen; Yun Long Tan; Shu Ping Tan; Li Hui; Men Han Lv; Jair C Soares; Xiang Yang Zhang
Journal:  Psychopharmacology (Berl)       Date:  2014-07-04       Impact factor: 4.530

6.  The medial and lateral substantia nigra in Parkinson's disease: mRNA profiles associated with higher brain tissue vulnerability.

Authors:  D C Duke; L B Moran; R K B Pearce; M B Graeber
Journal:  Neurogenetics       Date:  2007-01-09       Impact factor: 2.660

7.  An NR2B-Dependent Decrease in the Expression of trkB Receptors Precedes the Disappearance of Dopaminergic Cells in Substantia Nigra in a Rat Model of Presymptomatic Parkinson's Disease.

Authors:  Eduardo Riquelme; Jorge Abarca; Jorge M Campusano; Gonzalo Bustos
Journal:  Parkinsons Dis       Date:  2012-06-07

8.  Role of vitamin d in Parkinson's disease.

Authors:  Khanh L Ng; Lan Nguyễn
Journal:  ISRN Neurol       Date:  2012-03-07

9.  Interaction Effects of BDNF and COMT Genes on Resting-State Brain Activity and Working Memory.

Authors:  Wen Chen; Chunhui Chen; Mingrui Xia; Karen Wu; Chuansheng Chen; Qinghua He; Gui Xue; Wenjing Wang; Yong He; Qi Dong
Journal:  Front Hum Neurosci       Date:  2016-11-02       Impact factor: 3.169

10.  BDNF Val66Met variant and smoking in a Chinese population.

Authors:  Xiang Yang Zhang; Da Chun Chen; Mei Hong Xiu; Xingguang Luo; Lingjun Zuo; Colin N Haile; Therese A Kosten; Thomas R Kosten
Journal:  PLoS One       Date:  2012-12-28       Impact factor: 3.240
  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.