| Literature DB >> 9759473 |
G De Benedictis1, L Carotenuto, G Carrieri, M De Luca, E Falcone, G Rose, A I Yashin, M Bonafè, C Franceschi.
Abstract
The analysis of seven different age cohorts (697 individuals from 10 to 109 years old) revealed age-related changes in the 3'APOB-VNTR genotype pool. By recoding the 3'APOB-VNTR alleles into three size-classes (small, S, 26-34 repeats; medium, M, 35-39 repeats; large, L, 41-55 repeats), an age-related convex trajectory of the frequency of SS homozygotes was found. The frequency of SS in the genotype pool increased from the group aged 10-19 years (3.06 +/- 1.74%) to that aged 40-49 years (8.51 +/- 4.07%). Then it declined reaching the minimum value in centenarians (1.58 +/- 0.90%). The observed trajectory is in agreement with that expected by assuming crossing of mortality curves relevant to subgroups of individuals having different genotypes.Entities:
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Year: 1998 PMID： 9759473 DOI： 10.1046/j.1469-1809.1998.6220115.x
Source DB: PubMed Journal: Ann Hum Genet ISSN： 0003-4800 Impact factor: 1.670