Literature DB >> 9758855

Oxidation of morphine to 2,2'-bimorphine by cylindrocarpon didymum

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Abstract

The oxidation of morphine by whole-cell suspensions and cell extracts of Cylindrocarpon didymum gave rise to the formation of 2, 2'-bimorphine. The identity of 2,2'-bimorphine was confirmed by mass spectrometry and 1H nuclear magnetic resonance spectroscopy. C. didymum also displayed activity with the morphine analogs hydromorphone, 6-acetylmorphine, and dihydromorphine, but not codeine or diamorphine, suggesting that a phenolic group at C-3 is essential for activity.

Entities:  

Year:  1998        PMID： 9758855      PMCID： PMC106614     

Source DB:  PubMed          Journal:  Appl Environ Microbiol        ISSN： 0099-2240            Impact factor:   4.792


  5 in total

1.  Ion-pair high-performance liquid chromatographic determination of morphine and pseudomorphine in injections.

Authors:  M Dolezalová
Journal:  J Pharm Biomed Anal       Date:  1992-07       Impact factor: 3.935

2.  FLUOROMETRIC IDENTIFICATION OF SUB-MICROGRAM AMOUNTS OF MORPHINE AND RELATED COMPOUNDS ON THIN-LAYER CHROMATOGRAPHS.

Authors:  H J KUPFERBERG; A BURKHALTER; E L WAY
Journal:  J Chromatogr       Date:  1964-12

3.  The yields of Streptococcus faecalis grown in continuous culture.

Authors:  R F ROSENBERGER; S R ELSDEN
Journal:  J Gen Microbiol       Date:  1960-06

4.  A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.

Authors:  M M Bradford
Journal:  Anal Biochem       Date:  1976-05-07       Impact factor: 3.365

5.  Mechanisms of steroid oxidation by microorganisms. XI. Enzymatic cleavage of the pregnane side chain.

Authors:  M A Rahm; C J Sih
Journal:  J Biol Chem       Date:  1966-08-10       Impact factor: 5.157
  5 in total
  1 in total

1.  Transformation of 2,2'-bimorphine to the novel compounds 10-alpha-S-monohydroxy-2,2'-bimorphine and 10,10'-alpha,alpha'-S,S'-dihydroxy-2,2'-bimorphine by Cylindrocarpon didymum.

Authors:  P J Stabler; P J Holt; N C Bruce
Journal:  Appl Environ Microbiol       Date:  2001-08       Impact factor: 4.792
  1 in total

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