Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Linkage disequilibrium mapping of the gene for Margarita Island ectodermal dysplasia (ED4) to 11q23.

Literature DB >> 9758630

Linkage disequilibrium mapping of the gene for Margarita Island ectodermal dysplasia (ED4) to 11q23.

Abstract

Margarita Island ectodermal dysplasia (ED4) is an autosomal recessive disorder characterized by unusual facies, dental anomalies, hypotrichosis, palmoplantar hyperkeratosis and onychodysplasia, syndactyly, and cleft lip/cleft palate. We have used an affected-only DNA-pooling strategy to carry out linkage disequilibrium mapping of the ED4 gene to 11q23. Haplotype analysis of four complex Margarita Island ED4 families localized the ED4 gene to an approximately 1-2-Mb interval spanned by just two YACs.

Entities: Disease Gene

Mesh：

Substances：
Genetic Markers

Year: 1998 PMID： 9758630 PMCID： PMC1377504 DOI： 10.1086/302072

Source DB: PubMed Journal: Am J Hum Genet ISSN： 0002-9297 Impact factor: 11.025

13 in total

1. Syndactyly, ectodermal dysplasia, and cleft lip and palate.

Authors: J Zlotogora; G Ogur
Journal: J Med Genet Date: 1988-07 Impact factor: 6.318

2. Hypohidrotic ectodermal dysplasia in females. A critical analysis and argument for genetic heterogeneity.

Authors: R J Gorlin; T Old; V E Anderson
Journal: Z Kinderheilkd Date: 1970

3. Syndactyly, ectodermal dysplasia, and cleft lip/palate.

Authors: J Zlotogora
Journal: J Med Genet Date: 1994-12 Impact factor: 6.318

4. Cleft lip and palate, pili torti, malformed ears, partial syndactyly of fingers and toes, and mental retardation: a new syndrome?

Authors: J Zlotogora; Y Zilberman; A Tenenbaum; M R Wexler
Journal: J Med Genet Date: 1987-05 Impact factor: 6.318

5. An autosomal recessive nonsyndromic-hearing-loss locus identified by DNA pooling using two inbred Bedouin kindreds.

Authors: D A Scott; R Carmi; K Elbedour; S Yosefsberg; E M Stone; V C Sheffield
Journal: Am J Hum Genet Date: 1996-08 Impact factor: 11.025

6. Autosomal recessive ectodermal dysplasia, cleft lip/palate, mental retardation, and syndactyly: the Zlotogora-Ogur syndrome.

Authors: E S Rodini; A Richieri-Costa
Journal: Am J Med Genet Date: 1990-08

7. Use of a DNA pooling strategy to identify a human obesity syndrome locus on chromosome 15.

Authors: R Carmi; T Rokhlina; A E Kwitek-Black; K Elbedour; D Nishimura; E M Stone; V C Sheffield
Journal: Hum Mol Genet Date: 1995-01 Impact factor: 6.150

8. Homozygosity mapping: a way to map human recessive traits with the DNA of inbred children.

Authors: E S Lander; D Botstein
Journal: Science Date: 1987-06-19 Impact factor: 47.728

9. A gene causing Hermansky-Pudlak syndrome in a Puerto Rican population maps to chromosome 10q2.

Authors: S C Wildenberg; W S Oetting; C Almodóvar; M Krumwiede; J G White; R A King
Journal: Am J Hum Genet Date: 1995-10 Impact factor: 11.025

Review 10. Association of syndactyly, ectodermal dysplasia, and cleft lip and palate: report of two sibs from Turkey.

Authors: G Oğur; M Yüksel
Journal: J Med Genet Date: 1988-01 Impact factor: 6.318

5 in total

1. The cell adhesion molecules Echinoid and Friend of Echinoid coordinate cell adhesion and cell signaling to regulate the fidelity of ommatidial rotation in the Drosophila eye.

Authors: Jennifer L Fetting; Susan A Spencer; Tanya Wolff
Journal: Development Date: 2009-10 Impact factor: 6.868