OBJECTIVE: To compare serum leptin levels in normally cycling reproductive females (20-35 years old) with those in age-matched males, in women who were receiving oral contraceptives, and in older (postmenopausal) women (50-65 years old) who were or who were not receiving hormone replacement therapy. DESIGN: Case-control study. SETTING: Obstetrics and Gynecology Clinic, Texas Tech University Health Sciences Center-Amarillo, or the Exercise Physiology Laboratory at Southeastern Louisiana University. PATIENT(S): Normally cycling women between the ages of 20-35 years and age-matched controls who were receiving oral contraceptives. Postmenopausal women between the ages of 50-65 years who were or who were not receiving hormone replacement therapy. MAIN OUTCOME MEASURE(S): Serum leptin concentration. RESULT(S): In all groups, serum leptin concentrations were correlated significantly with body mass index. Leptin levels were significantly higher in young women than young men (P <.001), but no other statistically significant differences were found for the other three comparisons. CONCLUSION(S): Serum leptin concentrations expressed as a measure of adiposity (body mass index) are greater in young normally cycling females (20-35 years old) than in age-matched males. There is no difference in levels of serum leptin between young and postmenopausal (50-65 years old) women. Estrogen administration, either in young women who are receiving estrogen-progestin oral contraceptives or in postmenopausal women who are receiving hormone replacement therapy, does not effect serum leptin concentrations.
OBJECTIVE: To compare serum leptin levels in normally cycling reproductive females (20-35 years old) with those in age-matched males, in women who were receiving oral contraceptives, and in older (postmenopausal) women (50-65 years old) who were or who were not receiving hormone replacement therapy. DESIGN: Case-control study. SETTING: Obstetrics and Gynecology Clinic, Texas Tech University Health Sciences Center-Amarillo, or the Exercise Physiology Laboratory at Southeastern Louisiana University. PATIENT(S): Normally cycling women between the ages of 20-35 years and age-matched controls who were receiving oral contraceptives. Postmenopausal women between the ages of 50-65 years who were or who were not receiving hormone replacement therapy. MAIN OUTCOME MEASURE(S): Serum leptin concentration. RESULT(S): In all groups, serum leptin concentrations were correlated significantly with body mass index. Leptin levels were significantly higher in young women than young men (P <.001), but no other statistically significant differences were found for the other three comparisons. CONCLUSION(S): Serum leptin concentrations expressed as a measure of adiposity (body mass index) are greater in young normally cycling females (20-35 years old) than in age-matched males. There is no difference in levels of serum leptin between young and postmenopausal (50-65 years old) women. Estrogen administration, either in young women who are receiving estrogen-progestin oral contraceptives or in postmenopausal women who are receiving hormone replacement therapy, does not effect serum leptin concentrations.
Authors: Robert R Kraemer; Robert J Durand; Edmund O Acevedo; Lisa G Johnson; Linda B Synovitz; Ginger R Kraemer; Terry Gimpel; V Daniel Castracane Journal: Endocrine Date: 2003-08 Impact factor: 3.633
Authors: L Airaghi; P Usardi; S Forti; A Orsatti; M Baldini; C Annaloro; G Lambertenghi Deliliers Journal: J Endocrinol Invest Date: 2010-07-01 Impact factor: 4.256
Authors: Brian C Cooper; Natalie Z Burger; Michael J Toth; Mary Cushman; Cynthia K Sites Journal: Am J Obstet Gynecol Date: 2007-02 Impact factor: 8.661
Authors: Robert R Kraemer; Michelle Francois; Nancy Dardis Webb; Jennifer R Worley; Sharon N Rogers; Reid L Norman; Urvi Shah; V Daniel Castracane; V Daniel Castracane Journal: Eur J Appl Physiol Date: 2013-06-14 Impact factor: 3.078
Authors: Emma H Allott; Elizabeth Oliver; Joanne Lysaght; Steven G Gray; John V Reynolds; Helen M Roche; Graham P Pidgeon Journal: Clin Transl Oncol Date: 2012-08-02 Impact factor: 3.405