Literature DB >> 9757830

Nucleic-acid-chaperone activity of retroviral nucleocapsid proteins: significance for viral replication.

A Rein1, L E Henderson, J G Levin.   

Abstract

Retrovirus particles contain a small, basic protein, the nucleocapsid (NC) protein, that possesses 'nucleic acid chaperone' activity--that is, the NC protein can catalyze the rearrangement of a nucleic acid molecule into the conformation that has the maximal number of base pairs. The molecular mechanism that underlies this effect is not understood. Because the chaperone activity is apparently crucial during the infectious process, NC is a potential target for antiviral therapy.

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Year:  1998        PMID： 9757830     DOI： 10.1016/s0968-0004(98)01256-0

Source DB:  PubMed          Journal:  Trends Biochem Sci        ISSN： 0968-0004            Impact factor:   13.807


  194 in total

1.  Nucleic acid chaperone activity of the ORF1 protein from the mouse LINE-1 retrotransposon.

Authors:  S L Martin; F D Bushman
Journal:  Mol Cell Biol       Date:  2001-01       Impact factor: 4.272

2.  In vitro evidence for the interaction of tRNA(3)(Lys) with U3 during the first strand transfer of HIV-1 reverse transcription.

Authors:  F Brulé; G Bec; G Keith; S F Le Grice; B P Roques; B Ehresmann; C Ehresmann; R Marquet
Journal:  Nucleic Acids Res       Date:  2000-01-15       Impact factor: 16.971

3.  Copy-choice recombination by reverse transcriptases: reshuffling of genetic markers mediated by RNA chaperones.

Authors:  M Negroni; H Buc
Journal:  Proc Natl Acad Sci U S A       Date:  2000-06-06       Impact factor: 11.205

4.  Molecular basis of sequence-specific recognition of pre-ribosomal RNA by nucleolin.

Authors:  F H Allain; P Bouvet; T Dieckmann; J Feigon
Journal:  EMBO J       Date:  2000-12-15       Impact factor: 11.598

5.  Identification of residues of the Moloney murine leukemia virus nucleocapsid critical for viral DNA synthesis in vivo.

Authors:  J Gonsky; E Bacharach; S P Goff
Journal:  J Virol       Date:  2001-03       Impact factor: 5.103

6.  The human immunodeficiency virus type 1 Gag polyprotein has nucleic acid chaperone activity: possible role in dimerization of genomic RNA and placement of tRNA on the primer binding site.

Authors:  Y X Feng; S Campbell; D Harvin; B Ehresmann; C Ehresmann; A Rein
Journal:  J Virol       Date:  1999-05       Impact factor: 5.103

7.  The genomic RNA in Ty1 virus-like particles is dimeric.

Authors:  Y X Feng; S P Moore; D J Garfinkel; A Rein
Journal:  J Virol       Date:  2000-11       Impact factor: 5.103

8.  The HIV-1 repeated sequence R as a robust hot-spot for copy-choice recombination.

Authors:  A Moumen; L Polomack; B Roques; H Buc; M Negroni
Journal:  Nucleic Acids Res       Date:  2001-09-15       Impact factor: 16.971

9.  Human immunodeficiency virus type 1 N-terminal capsid mutants that exhibit aberrant core morphology and are blocked in initiation of reverse transcription in infected cells.

Authors:  S Tang; T Murakami; B E Agresta; S Campbell; E O Freed; J G Levin
Journal:  J Virol       Date:  2001-10       Impact factor: 5.103

Review 10.  Destiny of unspliced retroviral RNA: ribosome and/or virion?

Authors:  Melinda Butsch; Kathleen Boris-Lawrie
Journal:  J Virol       Date:  2002-04       Impact factor: 5.103
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