Literature DB >> 975753

Phencyclidine: tissue distribution in the rat.

S H James, S H Schnoll.   

Abstract

This study was performed to provide knowledge of the tissue distribution of phencyclidine and has demonstrated the lipophilic nature of the drug. The distribution of phencyclidine in blood, brain, and adipose tissue of rats has been determined at various time intervals during a 48-hr period. The affinity of phencyclidine for adipose tissue and the demonstration of the presence of this drug in brain tissue long after it is no longer detectable in blood provides some correlation between the tissue distribution of phencyclidine and its clinical manifestations occuring 24-48 hr after administration.

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Year:  1976        PMID： 975753     DOI： 10.3109/15563657608988159

Source DB:  PubMed          Journal:  Clin Toxicol        ISSN： 0009-9309            Impact factor:   4.467


  6 in total

1.  Persisting changes in brain glucose uptake following neurotoxic doses of phencyclidine which mirror the acute effects of the drug.

Authors:  G D Ellison; A S Keys
Journal:  Psychopharmacology (Berl)       Date:  1996-08       Impact factor: 4.530

2.  Phencyclidine: effects of chronic administration in the female mouse on gestation, maternal behavior, and the neonates.

Authors:  P J Goodwin; V J Perez; J C Eatwell; J L Palet; M T Jaworski
Journal:  Psychopharmacology (Berl)       Date:  1980       Impact factor: 4.530

3.  First dose behavioral tolerance to phencyclidine on food-rewarded bar pressing behavior in the rat.

Authors:  D M Ruffing; E F Domino
Journal:  Psychopharmacology (Berl)       Date:  1980       Impact factor: 4.530

4.  Changes in gene expression after phencyclidine administration in developing rats: a potential animal model for schizophrenia.

Authors:  F Liu; X Zou; N Sadovova; X Zhang; L Shi; L Guo; F Qian; Z Wen; T A Patterson; J P Hanig; M G Paule; W Slikker; C Wang
Journal:  Int J Dev Neurosci       Date:  2010-08-05       Impact factor: 2.457

5.  Whole body autoradiography of 3H-phencyclidine in mice.

Authors:  A Chari-Bitron; G A Simon; T Kadar; L Motola
Journal:  Arch Toxicol       Date:  1979-12       Impact factor: 5.153

6.  The dispositional kinetics of phencyclidine and its N-ethylamine analogue in rats.

Authors:  S Chakrabarti; F C Law
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1983 Oct-Dec       Impact factor: 2.441
  6 in total

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