Literature DB >> 9757030

Fatty acid incorporation depicts brain activity in a rat model of Parkinson's disease.

T Hayakawa1, M C Chang, J M Bell, R Seeman, S I Rapoport, N M Appel.   

Abstract

Following pulse labeling with [3H]arachidonic acid ([3H]AA), its incorporation pattern in brain reflects regional changes in neurotransmitter signal transduction using phospholipase A2, that is, functional activity. In a rat model of Parkinson's disease, unilateral 6-hydroxydopamine lesion in the substantia nigra, [3H]AA acid incorporation from blood was increased in cerebral cortex, caudate putamen, globus pallidus, entopeduncular nucleus, subthalamic nucleus and substantia nigra pars reticulata ipsilateral to the lesion. This increased [3H]AA incorporation likely reflects disinhibition of basal ganglia and cortical circuits secondary to absent inhibitory nigrostriatal dopaminergic input. Copyright 1998 Elsevier Science B.V.

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Year:  1998        PMID： 9757030     DOI： 10.1016/s0006-8993(98)00751-3

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  9 in total

1.  The utility of (11)C-arachidonate PET to study in vivo dopaminergic neurotransmission in humans.

Authors:  Madhav Thambisetty; Kathy A Gallardo; Jeih-San Liow; Lori L Beason-Held; John C Umhau; Abesh K Bhattacharjee; Margaret Der; Peter Herscovitch; Judith L Rapoport; Stanley I Rapoport
Journal:  J Cereb Blood Flow Metab       Date:  2011-12-14       Impact factor: 6.200

2.  [11 C]arachidonic acid incorporation measurement in human brain: Optimization for clinical use.

Authors:  Francesca Zanderigo; Yeona Kang; Dileep Kumar; Anastasia Nikolopoulou; P David Mozley; Paresh J Kothari; Bin He; David Schlyer; Stanley I Rapoport; Maria A Oquendo; Shankar Vallabhajosula; J John Mann; M Elizabeth Sublette
Journal:  Synapse       Date:  2017-11-27       Impact factor: 2.562

Review 3.  In vivo fatty acid incorporation into brain phosholipids in relation to plasma availability, signal transduction and membrane remodeling.

Authors:  S I Rapoport
Journal:  J Mol Neurosci       Date:  2001 Apr-Jun       Impact factor: 3.444

4.  Brain arachidonic acid cascade enzymes are upregulated in a rat model of unilateral Parkinson disease.

Authors:  Ho-Joo Lee; Richard P Bazinet; Stanley I Rapoport; Abesh Kumar Bhattacharjee
Journal:  Neurochem Res       Date:  2009-12-08       Impact factor: 3.996

Review 5.  In vivo fatty acid incorporation into brain phospholipids in relation to signal transduction and membrane remodeling.

Authors:  S I Rapoport
Journal:  Neurochem Res       Date:  1999-11       Impact factor: 3.996

6.  D2 but not D1 dopamine receptor stimulation augments brain signaling involving arachidonic acid in unanesthetized rats.

Authors:  Abesh Kumar Bhattacharjee; Lisa Chang; Ho-Joo Lee; Richard P Bazinet; Ruth Seemann; Stanley I Rapoport
Journal:  Psychopharmacology (Berl)       Date:  2005-09-14       Impact factor: 4.530

Review 7.  Imaging brain signal transduction and metabolism via arachidonic and docosahexaenoic acid in animals and humans.

Authors:  Mireille Basselin; Epolia Ramadan; Stanley I Rapoport
Journal:  Brain Res Bull       Date:  2011-12-09       Impact factor: 4.077

8.  Imaging apomorphine stimulation of brain arachidonic acid signaling via D2-like receptors in unanesthetized rats.

Authors:  Abesh Kumar Bhattacharjee; Lisa Chang; Laura White; Richard P Bazinet; Stanley I Rapoport
Journal:  Psychopharmacology (Berl)       Date:  2008-02-15       Impact factor: 4.530

9.  Major Alterations of Phosphatidylcholine and Lysophosphotidylcholine Lipids in the Substantia Nigra Using an Early Stage Model of Parkinson's Disease.

Authors:  Kyle Farmer; Catherine A Smith; Shawn Hayley; Jeffrey Smith
Journal:  Int J Mol Sci       Date:  2015-08-12       Impact factor: 5.923
  9 in total

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