Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 A new approach for early assessment of the epileptogenic potential of quinolones.

Literature DB >> 9756792

A new approach for early assessment of the epileptogenic potential of quinolones.

A Delon¹, C Pariat, P Courtois, S Bouquet, W Couet.

Abstract

The epileptogenic potential of pefloxacin and norfloxacin, two quinolone antibiotics, was investigated in vivo in three different animal species by measuring drug concentrations in cerebrospinal fluid (CSF), which is part of the biophase, at the onset of convulsions. Interestingly, the pefloxacin-to-norfloxacin concentration ratios in CSF were virtually constant across the species (7.0, 6.6, and 6.0 in mice, rats, and rabbits, respectively), suggesting that this approach could be used to predict the relative epileptogenic potential of quinolones in humans.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 1998 PMID： 9756792 PMCID： PMC105934

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

16 in total

1. Structure-epileptogenicity relationship of quinolones with special reference to their interaction with gamma-aminobutyric acid receptor sites.

Authors: K Akahane; M Sekiguchi; T Une; Y Osada
Journal: Antimicrob Agents Chemother Date: 1989-10 Impact factor: 5.191

2. Development of a new quantitative approach for the isobolographic assessment of the convulsant interaction between pefloxacin and theophylline in rats.

Authors: L M Levasseur; A Delon; W R Greco; P Faury; S Bouquet; W Couet
Journal: Pharm Res Date: 1998-07 Impact factor: 4.200

3. Kinetics of drug action in disease states. XXIV. Pharmacodynamics of diazepam and its active metabolites in rats.

Authors: P M Klockowski; G Levy
Journal: J Pharmacol Exp Ther Date: 1988-03 Impact factor: 4.030

4. Kinetics of drug action in disease states. I. Effect of infusion rate on phenobarbital concentrations in serum, brain and cerebrospinal fluid of normal rats at onset of loss of righting reflex.

Authors: M Danhof; G Levy
Journal: J Pharmacol Exp Ther Date: 1984-04 Impact factor: 4.030

5. Kinetics of drug action in disease states. XXVI: Effect of fever on the pharmacodynamics of theophylline-induced seizures in rats.

Authors: M Yasuhara; G Levy
Journal: J Pharm Sci Date: 1988-07 Impact factor: 3.534

6. Cerebrospinal fluid transport and disposition of the quinolones ciprofloxacin and pefloxacin in rats.

Authors: U Jaehde; M W Langemeijer; A G de Boer; D D Breimer
Journal: J Pharmacol Exp Ther Date: 1992-12 Impact factor: 4.030

7. Kinetics of drug action in disease states. XIX. Effect of experimental liver disease on the neurotoxicity of theophylline in rats.

Authors: I M Ramzan; M Yasuhara; G Levy
Journal: J Pharmacol Exp Ther Date: 1987-04 Impact factor: 4.030

8. Kinetics of drug action in disease states. XVI. Pharmacodynamics of theophylline-induced seizures in rats.

Authors: I M Ramzan; G Levy
Journal: J Pharmacol Exp Ther Date: 1986-03 Impact factor: 4.030

9. Kinetics of drug action in disease states. XXV. Effect of experimental hypovolemia on the pharmacodynamics and pharmacokinetics of desmethyldiazepam.

Authors: P M Klockowski; G Levy
Journal: J Pharmacol Exp Ther Date: 1988-05 Impact factor: 4.030

10. Inhibitory effects of quinolone antibacterial agents on gamma-aminobutyric acid binding to receptor sites in rat brain membranes.

Authors: A Tsuji; H Sato; Y Kume; I Tamai; E Okezaki; O Nagata; H Kato
Journal: Antimicrob Agents Chemother Date: 1988-02 Impact factor: 5.191

6 in total

1. Antagonistic interaction between the convulsant activities of pefloxacin and its main metabolite norfloxacin in rats.

Authors: A Delon; L M Levasseur; M Giraudon; S Bouquet; W Couet
Journal: Pharm Res Date: 1999-12 Impact factor: 4.200

2. Development of a new quantitative approach for the isobolographic assessment of the convulsant interaction between pefloxacin and theophylline in rats.

Authors: L M Levasseur; A Delon; W R Greco; P Faury; S Bouquet; W Couet
Journal: Pharm Res Date: 1998-07 Impact factor: 4.200

3. Convulsant and subconvulsant doses of norfloxacin in the presence and absence of biphenylacetic acid alter extracellular hippocampal glutamate but not gamma-aminobutyric acid levels in conscious rats.

Authors: I Smolders; C Gousseau; S Marchand; W Couet; G Ebinger; Y Michotte
Journal: Antimicrob Agents Chemother Date: 2002-02 Impact factor: 5.191

A new approach for early assessment of the epileptogenic potential of quinolones.

1. Structure-epileptogenicity relationship of quinolones with special reference to their interaction with gamma-aminobutyric acid receptor sites.

2. Development of a new quantitative approach for the isobolographic assessment of the convulsant interaction between pefloxacin and theophylline in rats.

3. Kinetics of drug action in disease states. XXIV. Pharmacodynamics of diazepam and its active metabolites in rats.

4. Kinetics of drug action in disease states. I. Effect of infusion rate on phenobarbital concentrations in serum, brain and cerebrospinal fluid of normal rats at onset of loss of righting reflex.

5. Kinetics of drug action in disease states. XXVI: Effect of fever on the pharmacodynamics of theophylline-induced seizures in rats.

6. Cerebrospinal fluid transport and disposition of the quinolones ciprofloxacin and pefloxacin in rats.

7. Kinetics of drug action in disease states. XIX. Effect of experimental liver disease on the neurotoxicity of theophylline in rats.

8. Kinetics of drug action in disease states. XVI. Pharmacodynamics of theophylline-induced seizures in rats.

9. Kinetics of drug action in disease states. XXV. Effect of experimental hypovolemia on the pharmacodynamics and pharmacokinetics of desmethyldiazepam.

10. Inhibitory effects of quinolone antibacterial agents on gamma-aminobutyric acid binding to receptor sites in rat brain membranes.

1. Antagonistic interaction between the convulsant activities of pefloxacin and its main metabolite norfloxacin in rats.

2. Development of a new quantitative approach for the isobolographic assessment of the convulsant interaction between pefloxacin and theophylline in rats.

3. Convulsant and subconvulsant doses of norfloxacin in the presence and absence of biphenylacetic acid alter extracellular hippocampal glutamate but not gamma-aminobutyric acid levels in conscious rats.

4. Pharmacokinetic-pharmacodynamic contributions to the convulsant activity of fluoroquinolones in rats.

5. Ciprofloxacin-associated choreoathetosis in a haemodialysis patient.

6. Development of a physiologically-based pharmacokinetic model of the rat central nervous system.