Study of alterations produced by cadmium and cadmium/lead administration during gestational and early lactation periods in the reproductive organs of the rat.

Administration of cadmium (10 mg/liter) and cadmium+lead (300 mg/liter) via drinking water to Wistar rats during gestation and early lactation until delivery and (5 days after parturition) damaged pup reproductive systems. The effects are additive in the decreased gonad weight and additive or even synergistic in the reduced DNA gonadal content. The effects on protein reduction are similar for both cations. In the testes, the effects of cadmium are more important in the reduction of seminiferous tubule diameter, whereas the effects of lead are more overt in the reduction of the number of prospermatogonia. Copyright 1998 Academic Press.