BACKGROUND AND PURPOSE: Inconsistent information about incidence and determinants of poststroke dementia might be related to patient attrition, partly because of nonapplicability of formal neuropsychological testing to a large proportion of patients registered in a definite setting. METHODS: Using a proxy-informant interview based on ICD-10 criteria, we determined dementia at stroke onset and 1 year after stroke in the 339 patients who survived, were available for follow-up, and were not demented at stroke onset of 635 patients entered over a 1-year period in a stroke registry taken at 2 community hospitals in Florence, Italy. RESULTS: Of the 339 patients, 57 (16.8%) proved to have poststroke dementia. These patients were older, more frequently female, and more often (multivariate odds ratio, 2.35; 95% CI, 1.21 to 4.58) had atrial fibrillation than those without dementia. Aphasia and the clinical features expressing the severity of the stroke event in the acute phase predicted poststroke dementia. CONCLUSIONS: In a hospital-based nonselected series of stroke survivors, despite the use of a method with low sensitivity for defining dementia, our study confirms that dementia is a frequent sequela of stroke and is mainly predicted by stroke severity. Certain determinants could be controlled in the prestroke phase, thus reducing its risk.
BACKGROUND AND PURPOSE: Inconsistent information about incidence and determinants of poststroke dementia might be related to patient attrition, partly because of nonapplicability of formal neuropsychological testing to a large proportion of patients registered in a definite setting. METHODS: Using a proxy-informant interview based on ICD-10 criteria, we determined dementia at stroke onset and 1 year after stroke in the 339 patients who survived, were available for follow-up, and were not demented at stroke onset of 635 patients entered over a 1-year period in a stroke registry taken at 2 community hospitals in Florence, Italy. RESULTS: Of the 339 patients, 57 (16.8%) proved to have poststroke dementia. These patients were older, more frequently female, and more often (multivariate odds ratio, 2.35; 95% CI, 1.21 to 4.58) had atrial fibrillation than those without dementia. Aphasia and the clinical features expressing the severity of the stroke event in the acute phase predicted poststroke dementia. CONCLUSIONS: In a hospital-based nonselected series of stroke survivors, despite the use of a method with low sensitivity for defining dementia, our study confirms that dementia is a frequent sequela of stroke and is mainly predicted by stroke severity. Certain determinants could be controlled in the prestroke phase, thus reducing its risk.
Authors: Qianyi Wang; Iván Mejía-Guevara; Pamela M Rist; Stefan Walter; Benjamin D Capistrant; M Maria Glymour Journal: Cerebrovasc Dis Date: 2014-03-25 Impact factor: 2.762
Authors: Deborah A Levine; Mary N Haan; Kenneth M Langa; Lewis B Morgenstern; John Neuhaus; Anne Lee; Lynda D Lisabeth Journal: J Stroke Cerebrovasc Dis Date: 2012-06-27 Impact factor: 2.136
Authors: Lin Y Chen; Faye L Lopez; Rebecca F Gottesman; Rachel R Huxley; Sunil K Agarwal; Laura Loehr; Thomas Mosley; Alvaro Alonso Journal: Stroke Date: 2014-07-22 Impact factor: 7.914
Authors: Sarah T Pendlebury; Ping-Jen Chen; Sarah J V Welch; Fiona C Cuthbertson; Rose M Wharton; Ziyah Mehta; Peter M Rothwell Journal: Stroke Date: 2015-05-07 Impact factor: 7.914