Literature DB >> 9755851

Anisoosmotic regulation of the Mi-2 autoantigen mRNA in H4IIE rat hepatoma cells and primary hepatocytes.

R Hammermann1, U Warskulat, D Häussinger.   

Abstract

Using the differential display polymerase chain reaction (DDRT-PCR) a 169 bp cDNA product, which is 88.8% homologous to the human Mi-2beta autoantigen, was identified in H4IIE rat hepatoma cells. At protein level 100% homology was found. The Mi-2 mRNA was downregulated after hypoosmotic exposure and upregulated after hyperosmotic exposure in H4IIE cells and rat hepatocytes. The human Mi-2 is an autoantigen in dermatomyositis and is a member of the SNF/RAD 54 helicase family. Accordingly, Mi-2 may not only be a target of osmosignalling but could also be involved in the osmosignalling pathway towards gene expression in H4IIE and liver parenchymal cells.

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Year:  1998        PMID： 9755851     DOI： 10.1016/s0014-5793(98)01030-8

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  5 in total

1.  Dermatomyositis associated with hepatocellular carcinoma in an elderly female patient with hepatitis C virus-related liver cirrhosis.

Authors:  Nobuyuki Toshikuni; Rikako Torigoe; Mikio Mitsunaga; Akiyoshi Omoto; Koji Nakashima
Journal:  World J Gastroenterol       Date:  2006-03-14       Impact factor: 5.742

2.  Reovirus-induced alteration in expression of apoptosis and DNA repair genes with potential roles in viral pathogenesis.

Authors:  Roberta L DeBiasi; Penny Clarke; Suzanne Meintzer; Robert Jotte; B K Kleinschmidt-Demasters; Gary L Johnson; Kenneth L Tyler
Journal:  J Virol       Date:  2003-08       Impact factor: 5.103

3.  HBV vaccine and dermatomyositis: is there an association?

Authors:  Arie Altman; Martine Szyper-Kravitz; Yehuda Shoenfeld
Journal:  Rheumatol Int       Date:  2007-11-23       Impact factor: 3.580

4.  Hepatocellular carcinoma presenting as polymyositis: a paraneoplastic syndrome.

Authors:  Dhiraj Kishore; Vishal Khurana; Amit Raj; Indarajeet Singh Gambhir; Amita Diwaker
Journal:  Ann Saudi Med       Date:  2011 Sep-Oct       Impact factor: 1.526

Review 5.  Dermatomyositis as an extrahepatic manifestation of hepatitis B virus-related hepatocellular carcinoma: A case report and literature review.

Authors:  Juqiang Han; Shuai Wang; Thomas Ngai Yeung Kwong; Jian Liu
Journal:  Medicine (Baltimore)       Date:  2018-08       Impact factor: 1.889
  5 in total

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