Literature DB >> 9755847

Electroporation-mediated gene transfer in cardiac tissue.

R L Harrison1, B J Byrne, L Tung.   

Abstract

Delivery of genes or macromolecules to cardiovascular tissues provides new therapeutic opportunities for the treatment of many acquired and inherited diseases. To investigate electroporation as a delivery method in cardiac tissue, embryonic chick hearts were studied for uptake of propidium iodide (PI) or DNA encoding either green fluorescent protein (GFP) or luciferase following electrical shock. PI uptake increased monotonically from 6% of heart tissue after 3 shocks to 77% with 12 shocks. GFP and luciferase expression varied in proportion to shock number, with detectable levels in all electrically treated hearts. Thus, electroporation promotes uptake of PI and DNA in cardiac tissue, suggesting further application of this method for therapeutic genes.

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Year:  1998        PMID： 9755847     DOI： 10.1016/s0014-5793(98)00987-9

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  24 in total

1.  Gene transfer to intact mesenteric arteries by electroporation.

Authors:  J B Martin; J L Young; J N Benoit; D A Dean
Journal:  J Vasc Res       Date:  2000 Sep-Oct       Impact factor: 1.934

Review 2.  Electroporation of the vasculature and the lung.

Authors:  David A Dean
Journal:  DNA Cell Biol       Date:  2003-12       Impact factor: 3.311

3.  Electroporation as a method for high-level nonviral gene transfer to the lung.

Authors:  D A Dean; D Machado-Aranda; K Blair-Parks; A V Yeldandi; J L Young
Journal:  Gene Ther       Date:  2003-09       Impact factor: 5.250

4.  Electroporation-induced inward current in voltage-clamped guinea pig ventricular myocytes.

Authors:  Oksana Dyachok; Pavel Zhabyeyev; Terence F McDonald
Journal:  J Membr Biol       Date:  2010-11-21       Impact factor: 1.843

Review 5.  Nonviral gene transfer to skeletal, smooth, and cardiac muscle in living animals.

Authors:  David A Dean
Journal:  Am J Physiol Cell Physiol       Date:  2005-08       Impact factor: 4.249

6.  Atria are more susceptible to electroporation than ventricles: implications for atrial stunning, shock-induced arrhythmia and defibrillation failure.

Authors:  Vadim V Fedorov; Geran Kostecki; Matt Hemphill; Igor R Efimov
Journal:  Heart Rhythm       Date:  2008-01-29       Impact factor: 6.343

Review 7.  Gene electrotransfer: from biophysical mechanisms to in vivo applications : Part 2 - In vivo developments and present clinical applications.

Authors:  Jean-Michel Escoffre; Chloé Mauroy; Thomas Portet; Luc Wasungu; Aurelie Paganin-Gioanni; Muriel Golzio; Justin Teissié; Marie-Pierre Rols
Journal:  Biophys Rev       Date:  2009-11-10

Review 8.  Myocardial gene transfer: routes and devices for regulation of transgene expression by modulation of cellular permeability.

Authors:  Michael G Katz; Anthony S Fargnoli; Charles R Bridges
Journal:  Hum Gene Ther       Date:  2013-04-01       Impact factor: 5.695

9.  Electroporation-mediated delivery of a naked DNA plasmid expressing VEGF to the porcine heart enhances protein expression.

Authors:  W G Marshall; B A Boone; J D Burgos; S I Gografe; M K Baldwin; M L Danielson; M J Larson; D R Caretto; Y Cruz; B Ferraro; L C Heller; K E Ugen; M J Jaroszeski; R Heller
Journal:  Gene Ther       Date:  2009-12-03       Impact factor: 5.250

10.  Electroporating fields target oxidatively damaged areas in the cell membrane.

Authors:  P Thomas Vernier; Zachary A Levine; Yu-Hsuan Wu; Vanessa Joubert; Matthew J Ziegler; Lluis M Mir; D Peter Tieleman
Journal:  PLoS One       Date:  2009-11-23       Impact factor: 3.240
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