BACKGROUND: A number of studies have shown that the serotonin receptor agonist meta-chlorophenylpiperazine (mCPP) can exacerbate symptoms in patients with obsessive-compulsive disorder (OCD). The aim of the present study was to study the effect of this compound on regional cerebral blood flow (rCBF) in patients and controls. METHODS:Seven OCD patients and 8 healthy controls were randomly allocated to a double-blind challenge study with mCPP (0.5 mg/kg orally). rCBF was measured by 99m-Tc-hexamethyl-propyleneamineoxime single photon emission computed tomography. RESULTS:mCPP did not induce OCD symptoms in patients, but caused a significant decrease in rCBF in OCD patients, but not in controls. The decrease was seen in the reference regions cerebellum and whole brain, and in the frontal cortex, caudate nucleus, putamen, and thalamus. CONCLUSIONS: The effect of mCPP on the reference regions in patients posed methodological problems in the normalization methods. A possible role of the cerebellum in OCD is discussed.
RCT Entities:
BACKGROUND: A number of studies have shown that the serotonin receptor agonist meta-chlorophenylpiperazine (mCPP) can exacerbate symptoms in patients with obsessive-compulsive disorder (OCD). The aim of the present study was to study the effect of this compound on regional cerebral blood flow (rCBF) in patients and controls. METHODS: Seven OCDpatients and 8 healthy controls were randomly allocated to a double-blind challenge study with mCPP (0.5 mg/kg orally). rCBF was measured by 99m-Tc-hexamethyl-propyleneamineoxime single photon emission computed tomography. RESULTS:mCPP did not induce OCD symptoms in patients, but caused a significant decrease in rCBF in OCDpatients, but not in controls. The decrease was seen in the reference regions cerebellum and whole brain, and in the frontal cortex, caudate nucleus, putamen, and thalamus. CONCLUSIONS: The effect of mCPP on the reference regions in patients posed methodological problems in the normalization methods. A possible role of the cerebellum in OCD is discussed.
Authors: Mark C Tucci; Anna Dvorkin-Gheva; Renee Sharma; Leena Taji; Paul Cheon; John Peel; Ashley Kirk; Henry Szechtman Journal: Psychopharmacology (Berl) Date: 2014-02-28 Impact factor: 4.530
Authors: Alexandre Berney; Marco Leyton; Paul Gravel; Igor Sibon; Debbie Sookman; Pedro Rosa Neto; Mirko Diksic; Akio Nakai; Gilbert Pinard; Christo Todorov; Hidehiko Okazawa; Pierre Blier; Thomas Edward Nordahl; Chawki Benkelfat Journal: Arch Gen Psychiatry Date: 2011-03-07
Authors: Mark C Tucci; Anna Dvorkin-Gheva; Dawn Graham; Sean Amodeo; Paul Cheon; Ashley Kirk; John Peel; Leena Taji; Henry Szechtman Journal: Psychopharmacology (Berl) Date: 2013-01-25 Impact factor: 4.530