Literature DB >> 9753126

Effect of heparin-binding growth-associated molecule (HB-GAM) on synaptic transmission and early LTP in rat hippocampal slices.

S E Lauri1, H Rauvala, K Kaila, T Taira.   

Abstract

Heparin-binding growth-associated molecule (HB-GAM) is an 18-kDa developmentally regulated protein, which promotes neurite outgrowth, axonal guidance and synaptogenesis through interaction with cell-surface heparan-sulphate proteoglycans. We have studied the effect of HB-GAM on synaptic transmission and long-term potentiation (LTP) in the area CA1 of rat hippocampal slices, where HB-GAM mRNA is expressed in an activity-dependent manner. Injection of recombinant HB-GAM into the dendritic area inhibited tetanus-induced LTP without affecting baseline synaptic responses or the N-methyl-D-aspartate (NMDA)-receptor mediated transmission. HB-GAM did not depotentiate tetanus-induced LTP or prevent heterosynaptic LTP induced by application of tetraethylammonium (TEA), indicating that the effect was limited to early, synapse-specific stages of LTP induction. These results suggest that HB-GAM is involved in the regulation of synaptic plasticity in hippocampus.

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Year:  1998        PMID： 9753126     DOI： 10.1046/j.1460-9568.1998.00039.x

Source DB:  PubMed          Journal:  Eur J Neurosci        ISSN： 0953-816X            Impact factor:   3.386


  7 in total

1.  Neuroglycan C, a brain-specific chondroitin sulfate proteoglycan, interacts with pleiotrophin, a heparin-binding growth factor.

Authors:  Keiko Nakanishi; Yoshihito Tokita; Sachiko Aono; Michiru Ida; Fumiko Matsui; Yujiro Higashi; Atsuhiko Oohira
Journal:  Neurochem Res       Date:  2010-04-06       Impact factor: 3.996

2.  Neural Precursor-Derived Pleiotrophin Mediates Subventricular Zone Invasion by Glioma.

Authors:  Elizabeth Y Qin; Dominique D Cooper; Keene L Abbott; James Lennon; Surya Nagaraja; Alan Mackay; Chris Jones; Hannes Vogel; Peter K Jackson; Michelle Monje
Journal:  Cell       Date:  2017-08-17       Impact factor: 41.582

3.  Impairment of L-type Ca2+ channel-dependent forms of hippocampal synaptic plasticity in mice deficient in the extracellular matrix glycoprotein tenascin-C.

Authors:  Matthias R Evers; Benedikt Salmen; Olena Bukalo; Astrid Rollenhagen; Michael R Bösl; Fabio Morellini; Udo Bartsch; Alexander Dityatev; Melitta Schachner
Journal:  J Neurosci       Date:  2002-08-15       Impact factor: 6.167

4.  Reg1ulatory role and molecular interactions of a cell-surface heparan sulfate proteoglycan (N-syndecan) in hippocampal long-term potentiation.

Authors:  S E Lauri; S Kaukinen; T Kinnunen; A Ylinen; S Imai; K Kaila; T Taira; H Rauvala
Journal:  J Neurosci       Date:  1999-02-15       Impact factor: 6.167

Review 5.  Pleiotrophin as a central nervous system neuromodulator, evidences from the hippocampus.

Authors:  Celia González-Castillo; Daniel Ortuño-Sahagún; Carolina Guzmán-Brambila; Mercè Pallàs; Argelia Esperanza Rojas-Mayorquín
Journal:  Front Cell Neurosci       Date:  2015-01-08       Impact factor: 5.505

6.  Genetic polymorphism of pleiotrophin is associated with pain experience in Japanese adults: Case-control study.

Authors:  Kosuke Saita; Masahiko Sumitani; Daisuke Nishizawa; Takashi Tamura; Kazutaka Ikeda; Kenji Wakai; Yoshika Sudo; Hiroaki Abe; Jun Otonari; Hiroaki Ikezaki; Kenji Takeuchi; Asahi Hishida; Keitaro Tanaka; Chisato Shimanoe; Toshiro Takezaki; Rie Ibusuki; Isao Oze; Hidemi Ito; Etsuko Ozaki; Daisuke Matsui; Yohko Nakamura; Miho Kusakabe; Sadao Suzuki; Hiroko Nakagawa-Senda; Kokichi Arisawa; Sakurako Katsuura-Kamano; Kiyonori Kuriki; Yoshikuni Kita; Yasuyuki Nakamura; Yukihide Momozawa; Kanji Uchida
Journal:  Medicine (Baltimore)       Date:  2022-09-16       Impact factor: 1.817

7.  Behavioral and neuroanatomical abnormalities in pleiotrophin knockout mice.

Authors:  Jason W Krellman; Henry H Ruiz; Veronica A Marciano; Bracha Mondrow; Susan D Croll
Journal:  PLoS One       Date:  2014-07-07       Impact factor: 3.240
  7 in total

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