Parcellation of human mesial area 6: cytoarchitectonic evidence for three separate areas.

The mesial sector of primate area 6 is usually described as consisting of two distinct areas: the supplementary motor area (SMA or SMA proper) and the pre-SMA. Recent human brain imaging studies showed, however, that this subdivision is not completely satisfactory and that, most likely, SMA proper consists of two functionally distinct parts. In order to elucidate whether this hypothesis has an anatomical counterpart, we examined the cytoarchitectonic organization of human mesial area 6 in three brains of subjects deceased without any previous sign of neurological disorders. The data showed that human mesial area 6 consists of three separate cytoarchitectonic areas. Two of them are located mostly caudal to the vertical line transversing the anterior commissure (VCA line), the third one is located rostral to it. Given the location and some architectonic similarities between the two caudal areas, we named them caudal SMA (SMAc) and rostral SMA (SMAr). The area rostral to the VCA line is referred to as pre-SMA. The possible functional role of the three areas is discussed.