S Suissa1, C Bourgault, A Barkun, O Sheehy, P Ernst. 1. Department of Epidemiology and Biostatistics, McGill University, the Royal Victoria Hospital, Montreal, Québec, Canada.
Abstract
PURPOSE: Calcium channel blockers have been reported to increase the risk of gastrointestinal bleeding. We tested this hypothesis, and also assessed whether beta blockers decrease this risk. SUBJECTS AND METHODS: A nested case-control design within a population-based cohort of all 34,074 new users of beta blockers, angiotensin-converting enzyme (ACE) inhibitors, or calcium channel blockers in Saskatchewan, from 1990 to 1993 and followed up to March 1995, was used. We identified all 311 subjects hospitalized because of gastrointestinal bleeding during this period, each of whom was matched to 10 randomly selected controls. RESULTS: The rate of hospitalization for gastrointestinal bleeding was 3.0 per 1,000 per year. The adjusted rate ratio of gastrointestinal bleeding for current use of calcium channel blockers was 1.1 (95% confidence interval [CI] 0.8 to 1.4) and 0.66 (95% CI 0.44 to 0.98) for beta blockers compared with no current use of anti-hypertensive drugs. The adjusted rate ratio for ACE inhibitor use was 1.0 (95% CI 0.7 to 1.3) while that for diuretic use was 1.4 (95% CI 1.0 to 2.0). CONCLUSIONS: The use of calcium channel blockers does not appear to increase the risk of gastrointestinal bleeding in the first five years of treatment, while beta blockers may prevent this adverse event. The unexpected elevated risk associated with the use of diuretics needs to be investigated further.
PURPOSE: Calcium channel blockers have been reported to increase the risk of gastrointestinal bleeding. We tested this hypothesis, and also assessed whether beta blockers decrease this risk. SUBJECTS AND METHODS: A nested case-control design within a population-based cohort of all 34,074 new users of beta blockers, angiotensin-converting enzyme (ACE) inhibitors, or calcium channel blockers in Saskatchewan, from 1990 to 1993 and followed up to March 1995, was used. We identified all 311 subjects hospitalized because of gastrointestinal bleeding during this period, each of whom was matched to 10 randomly selected controls. RESULTS: The rate of hospitalization for gastrointestinal bleeding was 3.0 per 1,000 per year. The adjusted rate ratio of gastrointestinal bleeding for current use of calcium channel blockers was 1.1 (95% confidence interval [CI] 0.8 to 1.4) and 0.66 (95% CI 0.44 to 0.98) for beta blockers compared with no current use of anti-hypertensive drugs. The adjusted rate ratio for ACE inhibitor use was 1.0 (95% CI 0.7 to 1.3) while that for diuretic use was 1.4 (95% CI 1.0 to 2.0). CONCLUSIONS: The use of calcium channel blockers does not appear to increase the risk of gastrointestinal bleeding in the first five years of treatment, while beta blockers may prevent this adverse event. The unexpected elevated risk associated with the use of diuretics needs to be investigated further.
Authors: Seng Chan You; Harlan M Krumholz; Marc A Suchard; Martijn J Schuemie; George Hripcsak; RuiJun Chen; Steven Shea; Jon Duke; Nicole Pratt; Christian G Reich; David Madigan; Patrick B Ryan; Rae Woong Park; Sungha Park Journal: Hypertension Date: 2021-03-29 Impact factor: 10.190
Authors: RuiJun Chen; Marc A Suchard; Harlan M Krumholz; Martijn J Schuemie; Steven Shea; Jon Duke; Nicole Pratt; Christian G Reich; David Madigan; Seng Chan You; Patrick B Ryan; George Hripcsak Journal: Hypertension Date: 2021-07-26 Impact factor: 9.897
Authors: William Phillips; Linda B Piller; Jeff D Williamson; Jeffrey Whittle; Syed Z A Jafri; Charles E Ford; Paula T Einhorn; Suzanne Oparil; Curt D Furberg; Richard H Grimm; Michael H Alderman; Barry R Davis; Jeffrey L Probstfield Journal: J Clin Hypertens (Greenwich) Date: 2013-08-07 Impact factor: 3.738