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Literature DB >> 97515

New regulatory mutations affecting the expression of the threonine operon in Escherichia coli K-12.

Abstract

The promoter of the threonine operon was joined to the structural genes of the lac operon in Escherichia coli K 12. The synthesis of beta-galactosidase was thus repressed by threonine plus isoleucine in the fusion strains. To isolate mutations which affect the expression of the threonine operon, alterations in the level of expression of the lacZ gene were selected. A new type of regulatory mutation was discovered.

Entities: Chemical Species

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Year: 1978 PMID： 97515 DOI： 10.1007/bf00333855

Source DB: PubMed Journal: Mol Gen Genet ISSN： 0026-8925

14 in total

1. Determination of serum proteins by means of the biuret reaction.

Authors: A G GORNALL; C J BARDAWILL; M M DAVID
Journal: J Biol Chem Date: 1949-02 Impact factor: 5.157

2. Revised structure of aspartokinase I-homoserine dehydrogenase I of Escherichia coli K12. Evidence for four identical subunits.

Authors: F Falcoz-Kelly; J Janin; J C Saari; M Véron; P Truffa-Bachi; G N Cohen
Journal: Eur J Biochem Date: 1972-08-04

3. Prophage lambda at unusual chromosomal locations. II. Mutations induced by bacteriophage lambda in Escherichia coli K12.

Authors: K Shimada; R A Weisberg; M E Gottesman
Journal: J Mol Biol Date: 1973-10-25 Impact factor: 5.469

3. New regulatory genes involved in the control of transcription initiation at the thr and ilv promoters of Escherichia coli K-12.

Authors: D I Johnson; R L Somerville
Journal: Mol Gen Genet Date: 1984

4. DNA sequence change of a deletion mutation abolishing attenuation control of the threonine operon of E. coli K12.

Authors: C Parsot; I Saint-Girons; P Cossart
Journal: Mol Gen Genet Date: 1982

5. Attenuation in the threonine operon: effects of amino acids present in the presumed leader peptide in addition to threonine and isoleucine.

Authors: J Daniel; I Saint-Girons
Journal: Mol Gen Genet Date: 1982

9. Regulation of the threonine operon: tandem threonine and isoleucine codons in the control region and translational control of transcription termination.

Authors: J F Gardner
Journal: Proc Natl Acad Sci U S A Date: 1979-04 Impact factor: 11.205

10. Threonine tRNAs and their genes in Escherichia coli.

Authors: M M Comer
Journal: Mol Gen Genet Date: 1982

New regulatory mutations affecting the expression of the threonine operon in Escherichia coli K-12.

1. Determination of serum proteins by means of the biuret reaction.

2. Revised structure of aspartokinase I-homoserine dehydrogenase I of Escherichia coli K12. Evidence for four identical subunits.

3. Prophage lambda at unusual chromosomal locations. II. Mutations induced by bacteriophage lambda in Escherichia coli K12.

4. Regulation of the regulatory gene for the arabinose pathway, araC.

5. Bacteriophage Mu integration: on the mechanism of Mu-induced mutations.

6. Operator-constitutive mutants in the threonine operon of Escherichia coli K-12.

7. Operator-promoter functions in the threonine operon of Escherichia coli.

8. Isoleucine and valine metabolism of Escherichia coli. XIV. Effect of thiaisoleucine.

9. A simple method for making new transducing lines of coliphage lambda.

10. Threonine locus of Escherichia coli K-12: genetic structure and evidence for an operon.

Review 1. Uses of lac fusions for the study of biological problems.

2. Fusion of the lac genes to the promoter for the aminopeptidase N gene of Escherichia coli.

3. New regulatory genes involved in the control of transcription initiation at the thr and ilv promoters of Escherichia coli K-12.

4. DNA sequence change of a deletion mutation abolishing attenuation control of the threonine operon of E. coli K12.

5. Attenuation in the threonine operon: effects of amino acids present in the presumed leader peptide in addition to threonine and isoleucine.

6. Regulation of aspartokinase III synthesis in Escherichia coli: isolation of mutants containing lysC-lac fusions.

7. Gene organization around the phenylalanyl-transfer ribonucleic acid synthetase locus in Escherichia coli.

8. Mutants which make more malT product, the activator of the maltose regulon in Escherichia coli.

9. Regulation of the threonine operon: tandem threonine and isoleucine codons in the control region and translational control of transcription termination.

10. Threonine tRNAs and their genes in Escherichia coli.