OBJECTIVE: To describe function and identify factors that affect outcome in dogs undergoing limb salvage surgery for osteosarcoma (OS) of the proximal humerus. STUDY DESIGN: A retrospective study of dogs in which OS of the proximal humerus was treated with limb salvage surgery. ANIMALS: 17 client-owned dogs. METHODS: Records were analyzed for functional outcome, recurrence, metastasis, and survival. RESULTS: Outcome was good to excellent in 12% of dogs. Recurrence, metastasis, and survival were significantly affected by completeness of surgical margins. Double plating of the distal allograft-host junction significantly reduced frequency of biomechanical failure. CONCLUSIONS: Limb salvage surgery for OS of the proximal humerus did not result in acceptable function and was fraught with postoperative complications. Outcome was significantly affected by completeness of surgical margins. CLINICAL RELEVANCE: Limb salvage surgery for OS of the proximal humerus in dogs cannot be recommended until improvement in functional outcome and reduction in postoperative complications can be achieved. The dependence of outcome on completeness of surgical margins supports aggressive en bloc resection and marking and evaluating surgical margins.
OBJECTIVE: To describe function and identify factors that affect outcome in dogs undergoing limb salvage surgery for osteosarcoma (OS) of the proximal humerus. STUDY DESIGN: A retrospective study of dogs in which OS of the proximal humerus was treated with limb salvage surgery. ANIMALS: 17 client-owned dogs. METHODS: Records were analyzed for functional outcome, recurrence, metastasis, and survival. RESULTS: Outcome was good to excellent in 12% of dogs. Recurrence, metastasis, and survival were significantly affected by completeness of surgical margins. Double plating of the distal allograft-host junction significantly reduced frequency of biomechanical failure. CONCLUSIONS: Limb salvage surgery for OS of the proximal humerus did not result in acceptable function and was fraught with postoperative complications. Outcome was significantly affected by completeness of surgical margins. CLINICAL RELEVANCE: Limb salvage surgery for OS of the proximal humerus in dogs cannot be recommended until improvement in functional outcome and reduction in postoperative complications can be achieved. The dependence of outcome on completeness of surgical margins supports aggressive en bloc resection and marking and evaluating surgical margins.
Authors: Ketaki S Karnik; Valerie F Samii; Steven E Weisbrode; Cheryl A London; Eric M Green Journal: Vet Radiol Ultrasound Date: 2012-03-14 Impact factor: 1.363
Authors: William T N Culp; Francisco Olea-Popelka; Jennifer Sefton; Charles F Aldridge; Stephen J Withrow; Mary H Lafferty; Robert B Rebhun; Michael S Kent; Nicole Ehrhart Journal: J Am Vet Med Assoc Date: 2014-11-15 Impact factor: 1.936
Authors: Tiffany Wormhoudt Martin; Lynn Griffin; James Custis; Stewart D Ryan; Mary Lafferty; Mary-Keara Boss; Daniel Regan; Sangeeta Rao; Del Leary; Stephen J Withrow; Susan M LaRue Journal: Vet Comp Oncol Date: 2021-01-13 Impact factor: 2.385
Authors: Cheryl A London; Heather L Gardner; Tamra Mathie; Nicole Stingle; Roberta Portela; Michael L Pennell; Craig A Clifford; Mona P Rosenberg; David M Vail; Laurel E Williams; Kim L Cronin; Heather Wilson-Robles; Antonella Borgatti; Carolyn J Henry; Dennis B Bailey; Jennifer Locke; Nicole C Northrup; Martin Crawford-Jakubiak; Virginia L Gill; Mary K Klein; David M Ruslander; Doug H Thamm; Brenda Phillips; Gerald Post Journal: PLoS One Date: 2015-04-29 Impact factor: 3.240