Literature DB >> 9747541

Antimycobacterial evaluation of germacranolides.

N H Fischer1, T Lu, C L Cantrell, J Castañeda-Acosta, L Quijano, S G Franzblau.   

Abstract

The minimum inhibitory concentrations (MIC) against Mycobacterium tuberculosis and M. avium of parthenolide, costunolide, 1 (10)-epoxycostunolide and other germacranolide-type sesquiterpene lactones and derivatives were determined by use of a radiorespirometric bioassay. Structure-activity relationship studies with natural and semisynthetic sesquiterpene lactones suggested that the alpha-methylene-gamma-lactone moiety is an essential, but not sufficient, structural requirement for significant in vitro activity against M. tuberculosis and M. avium.

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Year:  1998        PMID： 9747541     DOI： 10.1016/s0031-9422(98)00253-2

Source DB:  PubMed          Journal:  Phytochemistry        ISSN： 0031-9422            Impact factor:   4.072


  5 in total

1.  Antileishmanial activity of parthenolide, a sesquiterpene lactone isolated from Tanacetum parthenium.

Authors:  Tatiana Shioji Tiuman; Tânia Ueda-Nakamura; Diógenes Aparício Garcia Cortez; Benedito Prado Dias Filho; José Andrés Morgado-Díaz; Wanderley de Souza; Celso Vataru Nakamura
Journal:  Antimicrob Agents Chemother       Date:  2005-01       Impact factor: 5.191

2.  Processing of a sesquiterpene lactone by Papilio glaucus caterpillars.

Authors:  Cheryl Frankfater; Wolfgang Schühly; Frank R Fronczek; Marc Slattery
Journal:  J Chem Ecol       Date:  2005-10-25       Impact factor: 2.626

3.  Estimation of Costunolide and Dehydrocostus Lactone in Saussurea lappa and its Polyherbal Formulations followed by their Stability Studies Using HPLC-DAD.

Authors:  P R Rao Vadaparthi; K Kumar; Vanka Uma Maheswara Sarma; Qazi Altaf Hussain; K Suresh Babu
Journal:  Pharmacogn Mag       Date:  2015 Jan-Mar       Impact factor: 1.085

4.  Antioxidant activities of Melittis melissophyllum L. (Lamiaceae).

Authors:  Biljana Kaurinovic; Mira Popovic; Sanja Vlaisavljevic; Milena Raseta
Journal:  Molecules       Date:  2011-04-14       Impact factor: 4.411

5.  Simultaneous determination of three sesquiterpene lactones in Aucklandia lappa Decne by high-performance liquid chromatography.

Authors:  Chang-Seob Seo; Hyeun-Kyoo Shin
Journal:  Pharmacogn Mag       Date:  2015 Jul-Sep       Impact factor: 1.085
  5 in total

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