Literature DB >> 9746605

Localization of a T-cell epitope of superantigen toxic shock syndrome toxin 1 to residues 125 to 158.

W G Hu1, X H Zhu, Y Z Wu, Z C Jia.   

Abstract

Toxic shock syndrome toxin 1 (TSST-1) is a member of the staphylococcal enterotoxin superantigen family. So far, little is known about T-cell epitopes on superantigens. In this study, we developed an improved method for localizing T-cell epitopes on superantigens that involved synthetic peptides plus costimulation by CD28 or phorbol myristate acetate. Using this method, we localized a T-cell epitope to a 34-residue region, TSST-1 (residues 125 to 158), which possessed only two of four TSST-1-targeted beta-chain variable element (Vbeta) specificities of T-cell receptors in humans and mice, human Vbeta2 and murine Vbeta15.

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Year:  1998        PMID： 9746605      PMCID： PMC108616     

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  39 in total

1.  CD28 cross-linking augments TCR-mediated signals and costimulates superantigen responses.

Authors:  H Ohnishi; J A Ledbetter; S B Kanner; P S Linsley; T Tanaka; A M Geller; M Kotb
Journal:  J Immunol       Date:  1995-04-01       Impact factor: 5.422

2.  Universally immunogenic T cell epitopes: promiscuous binding to human MHC class II and promiscuous recognition by T cells.

Authors:  P Panina-Bordignon; A Tan; A Termijtelen; S Demotz; G Corradin; A Lanzavecchia
Journal:  Eur J Immunol       Date:  1989-12       Impact factor: 5.532

3.  A toxic shock syndrome toxin-1 peptide that shows homology to amino acids 180-193 of mycobacterial heat shock protein 65 is presented as conventional antigen.

Authors:  N Ramesh; P Parronchi; D Ahern; S Romagnani; R Geha
Journal:  Immunol Invest       Date:  1994-11       Impact factor: 3.657

4.  Localization of binding sites of staphylococcal enterotoxin B (SEB), a superantigen, for HLA-DR by inhibition with synthetic peptides of SEB.

Authors:  J L Komisar; S Small-Harris; J Tseng
Journal:  Infect Immun       Date:  1994-11       Impact factor: 3.441

5.  Multiple binding sites on the superantigen, staphylococcal enterotoxin B, imparts versatility in binding to MHC class II molecules.

Authors:  J M Soos; H M Johnson
Journal:  Biochem Biophys Res Commun       Date:  1994-06-15       Impact factor: 3.575

6.  Evidence for superantigen involvement in insulin-dependent diabetes mellitus aetiology.

Authors:  B Conrad; E Weidmann; G Trucco; W A Rudert; R Behboo; C Ricordi; H Rodriquez-Rilo; D Finegold; M Trucco
Journal:  Nature       Date:  1994-09-22       Impact factor: 49.962

7.  Mutations affecting the activity of toxic shock syndrome toxin-1.

Authors:  R L Deresiewicz; J Woo; M Chan; R W Finberg; D L Kasper
Journal:  Biochemistry       Date:  1994-11-01       Impact factor: 3.162

8.  A mutation at histidine residue 135 of toxic shock syndrome toxin yields an immunogenic protein with minimal toxicity.

Authors:  P F Bonventre; H Heeg; C K Edwards; C M Cullen
Journal:  Infect Immun       Date:  1995-02       Impact factor: 3.441

9.  Role of a carboxy-terminal site of toxic shock syndrome toxin 1 in eliciting immune responses of human peripheral blood mononuclear cells.

Authors:  A Drynda; B König; P F Bonventre; W König
Journal:  Infect Immun       Date:  1995-03       Impact factor: 3.441

10.  Evidence for a superantigen in human tuberculosis.

Authors:  J D Ohmen; P F Barnes; C L Grisso; B R Bloom; R L Modlin
Journal:  Immunity       Date:  1994-04       Impact factor: 31.745
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