Literature DB >> 9745690

Radiochemical purification of no-carrier-added scandium-47 for radioimmunotherapy.

K L Kolsky1, V Joshi, L F Mausner, S C Srivastava.   

Abstract

A procedure, adaptable to large-scale remote operation, was developed to purify no-carrier-added (NCA) 47Sc from irradiated Ti targets. Methods based on extraction chromatography and cation-exchange chromatography were compared. Results of this comparison led to the development of an optimized procedure based on cation-exchange with Dowex AG 50W-X4 and 47Sc elution with HCl/HF. This method gave 90-97% overall 47Sc recovery, with a Ti separation factor greater than 2.4 x 10(-5), and specific activities > or = 0.9 GBq microgram-1. Use of the 47Sc product, for labeling monoclonal antibodies, resulted in consistent labeling yields of > or = 90%.

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Year:  1998        PMID： 9745690     DOI： 10.1016/s0969-8043(98)00016-5

Source DB:  PubMed          Journal:  Appl Radiat Isot        ISSN： 0969-8043            Impact factor:   1.513


  14 in total

1.  ARRONAX, a high-energy and high-intensity cyclotron for nuclear medicine.

Authors:  Ferid Haddad; Ludovic Ferrer; Arnaud Guertin; Thomas Carlier; Nathalie Michel; Jacques Barbet; Jean-François Chatal
Journal:  Eur J Nucl Med Mol Imaging       Date:  2008-05-09       Impact factor: 9.236

Review 2.  Cutting edge rare earth radiometals: prospects for cancer theranostics.

Authors:  Alexander W E Sadler; Leena Hogan; Benjamin Fraser; Louis M Rendina
Journal:  EJNMMI Radiopharm Chem       Date:  2022-08-26

3.  Stability of 47Sc-complexes with acyclic polyamino-polycarboxylate ligands.

Authors:  Magdalena Połosak; Agata Piotrowska; Seweryn Krajewski; Aleksander Bilewicz
Journal:  J Radioanal Nucl Chem       Date:  2012-09-13       Impact factor: 1.371

4.  47Sc production development by cyclotron irradiation of 48Ca.

Authors:  R Misiak; R Walczak; B Wąs; M Bartyzel; J W Mietelski; A Bilewicz
Journal:  J Radioanal Nucl Chem       Date:  2017-06-13       Impact factor: 1.371

5.  47Sc as useful β--emitter for the radiotheragnostic paradigm: a comparative study of feasible production routes.

Authors:  Katharina A Domnanich; Cristina Müller; Martina Benešová; Rugard Dressler; Stephanie Haller; Ulli Köster; Bernard Ponsard; Roger Schibli; Andreas Türler; Nicholas P van der Meulen
Journal:  EJNMMI Radiopharm Chem       Date:  2017-06-02

6.  Production and separation of 43Sc for radiopharmaceutical purposes.

Authors:  Katharina A Domnanich; Robert Eichler; Cristina Müller; Sara Jordi; Vera Yakusheva; Saverio Braccini; Martin Behe; Roger Schibli; Andreas Türler; Nicholas P van der Meulen
Journal:  EJNMMI Radiopharm Chem       Date:  2017-11-25

7.  Production, biodistribution, and dosimetry of (47)Sc-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetramethylene phosphonic acid as a bone-seeking radiopharmaceutical.

Authors:  Fatemeh Fathi; Leila Moghaddam-Banaem; Mojtaba Shamsaei; Ali Samani; Mohammad G Maragheh
Journal:  J Med Phys       Date:  2015 Jul-Sep

8.  (44)Sc: an attractive isotope for peptide-based PET imaging.

Authors:  Reinier Hernandez; Hector F Valdovinos; Yunan Yang; Rubel Chakravarty; Hao Hong; Todd E Barnhart; Weibo Cai
Journal:  Mol Pharm       Date:  2014-07-23       Impact factor: 4.939

9.  Comparison between Three Promising ß-emitting Radionuclides, (67)Cu, (47)Sc and (161)Tb, with Emphasis on Doses Delivered to Minimal Residual Disease.

Authors:  Christophe Champion; Michele A Quinto; Clément Morgat; Paolo Zanotti-Fregonara; Elif Hindié
Journal:  Theranostics       Date:  2016-06-18       Impact factor: 11.556

10.  Cyclotron production of (43)Sc for PET imaging.

Authors:  Rafał Walczak; Seweryn Krajewski; Katarzyna Szkliniarz; Mateusz Sitarz; Kamel Abbas; Jarosław Choiński; Andrzej Jakubowski; Jerzy Jastrzębski; Agnieszka Majkowska; Federica Simonelli; Anna Stolarz; Agnieszka Trzcińska; Wiktor Zipper; Aleksander Bilewicz
Journal:  EJNMMI Phys       Date:  2015-12-04
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