Literature DB >> 9745687

The gallium-deferoxamine complex: stability with different deferoxamine concentrations and incubation conditions.

C Caraco1, L Aloj, W C Eckelman.   

Abstract

Previous studies report that deferoxamine (DFO) binds metallic ions such as Fe3+, In3+ and Ga3+ with very high affinity. This property of DFO has been utilized to label DFO-coupled compounds with radiometals such as 67Ga and 111In. We have studied the effect of low DFO concentrations and of different incubation conditions on the stability of the 67Ga-DFO complex. In our experience high (> 5 microM) DFO concentration appears to be critical in obtaining high radiochemical purity of such complexes.

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Year:  1998        PMID： 9745687     DOI： 10.1016/s0969-8043(97)10107-5

Source DB:  PubMed          Journal:  Appl Radiat Isot        ISSN： 0969-8043            Impact factor:   1.513


  6 in total

1.  Radiolabelling DOTA-peptides with 68Ga.

Authors:  Wouter A P Breeman; Marion de Jong; Erik de Blois; Bert F Bernard; Mark Konijnenberg; Eric P Krenning
Journal:  Eur J Nucl Med Mol Imaging       Date:  2005-01-18       Impact factor: 9.236

2.  Development of new folate-based PET radiotracers: preclinical evaluation of ⁶⁸Ga-DOTA-folate conjugates.

Authors:  Melpomeni Fani; Xuejuan Wang; Guillaume Nicolas; Christelle Medina; Isabelle Raynal; Marc Port; Helmut R Maecke
Journal:  Eur J Nucl Med Mol Imaging       Date:  2010-08-27       Impact factor: 9.236

3.  Facile labelling of an anti-epidermal growth factor receptor Nanobody with 68Ga via a novel bifunctional desferal chelate for immuno-PET.

Authors:  Maria J W D Vosjan; Lars R Perk; Rob C Roovers; Gerard W M Visser; Marijke Stigter-van Walsum; Paul M P van Bergen En Henegouwen; Guus A M S van Dongen
Journal:  Eur J Nucl Med Mol Imaging       Date:  2011-01-06       Impact factor: 9.236

4.  Fusarinine C, a novel siderophore-based bifunctional chelator for radiolabeling with Gallium-68.

Authors:  Chuangyan Zhai; Dominik Summer; Christine Rangger; Hubertus Haas; Roland Haubner; Clemens Decristoforo
Journal:  J Labelled Comp Radiopharm       Date:  2015-04-15       Impact factor: 1.921

Review 5.  Siderophores for molecular imaging applications.

Authors:  Milos Petrik; Chuangyan Zhai; Hubertus Haas; Clemens Decristoforo
Journal:  Clin Transl Imaging       Date:  2016-10-11

6.  Tuning the properties of tris(hydroxypyridinone) ligands: efficient 68Ga chelators for PET imaging.

Authors:  Cinzia Imberti; Yu-Lin Chen; Calum A Foley; Michelle T Ma; Brett M Paterson; Yifu Wang; Jennifer D Young; Robert C Hider; Philip J Blower
Journal:  Dalton Trans       Date:  2019-03-26       Impact factor: 4.390
  6 in total

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