Literature DB >> 974373

Action of surugatoxin on nicotinic receptors in the superior cervical ganglion of the rat.

D A Brown, J Garthwaite.   

Abstract

Surugatoxin (SGTX, 0.1-2 muM) reversibly depressed orthodromic transmission and antagonized the depolarizing action of carbachol on the isolated superior cervical ganglion of the rat. The apparent dissociation equilibrium constant against carbachol-induced depolarization (measured in the presence of hyoscine) was 58 and 76 nM determined at 0.2 and 2 muM respectively. SGTX (2muM) did not reduce the depolarizing effects of (+/-)-muscarine, gamma-aminobutyric acid or angiotensin, but did reduce that to 5-hydroxytryptamine. Release of [3H]-acetylcholine following repetitive (10 Hz) preganglionic sympathetic stimulation was maintained in the presence of 2 muM SGTX. It is concluded that SGTX has a high and selective affinity for ganglionic nicotinic receptors.

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Year:  1976        PMID： 974373      PMCID： PMC1667125          DOI： 10.1111/j.1476-5381.1976.tb07705.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  2 in total

1.  Evidence against a presynaptic action of acetylcholine during ganglionic transmission.

Authors:  D A Brown; K B Jones; J V Halliwell; J P Quilliam
Journal:  Nature       Date:  1970-06-06       Impact factor: 49.962

2.  Pharmacological studies on surugatoxin, the toxic principle from Japanese ivory mollusc (Babylonia japonica).

Authors:  E Hayashi; S Yamada
Journal:  Br J Pharmacol       Date:  1975-02       Impact factor: 8.739
  2 in total
  6 in total

1.  The effects of neosurugatoxin on evoked catecholamine secretion from bovine adrenal chromaffin cells.

Authors:  J E Bourke; S J Bunn; P D Marley; B G Livett
Journal:  Br J Pharmacol       Date:  1988-02       Impact factor: 8.739

2.  Synaptic localization of alpha-bungarotoxin binding which blocks nicotinic transmission at frog sympathetic neurons.

Authors:  L M Marshall
Journal:  Proc Natl Acad Sci U S A       Date:  1981-03       Impact factor: 11.205

Review 3.  Marine Origin Ligands of Nicotinic Receptors: Low Molecular Compounds, Peptides and Proteins for Fundamental Research and Practical Applications.

Authors:  Igor Kasheverov; Denis Kudryavtsev; Irina Shelukhina; Georgy Nikolaev; Yuri Utkin; Victor Tsetlin
Journal:  Biomolecules       Date:  2022-01-23

4.  Bispyridinium (oxime) compounds antagonize the "ganglion blocking" effect of pyridostigmine in isolated superior cervical ganglia of the rat.

Authors:  C Schlagmann; H Ulbrich; J Remien
Journal:  Arch Toxicol       Date:  1990       Impact factor: 5.153

5.  Studies on the mechanism of action of acetylcholine antagonists on rat parasympathetic ganglion cells.

Authors:  P Ascher; W A Large; H P Rang
Journal:  J Physiol       Date:  1979-10       Impact factor: 5.182

6.  The effect of neosurugatoxin on the release of neurohypophysial hormones by nicotine, hypotension and an osmotic stimulus in the rat.

Authors:  G W Bisset; K M Fairhall; K Tsuji
Journal:  Br J Pharmacol       Date:  1992-07       Impact factor: 8.739
  6 in total

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