Literature DB >> 9742940

A new human nm23 homologue (nm23-H5) specifically expressed in testis germinal cells.

A Munier1, C Feral, L Milon, V P Pinon, G Gyapay, J Capeau, G Guellaen, M L Lacombe.   

Abstract

We have identified a cDNA encoding a 212 amino acid protein (Nm23-H5) with 27-31% identity to the human members of the nm23/nucleoside diphosphate (NDP) kinase gene family. The nm23-H5 gene is located on chromosome 5q23-31 and is transcribed as one main transcript of 1.1 kb which is highly and specifically expressed in testis, in the spermatogonia and early spermatocytes. Nm23-H5 possesses most of the residues conserved among NDP kinases plus an additional COOH-terminus end of 55 amino acids unique to this protein. However, under usual assay conditions, Nm23-H5 expressed in Escherichia coli did not exhibit NDP kinase activity. These results suggest that Nm23-H5 is specifically involved in early stages of spermatogenesis.

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Year:  1998        PMID： 9742940     DOI： 10.1016/s0014-5793(98)00996-x

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  33 in total

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7.  Epstein-Barr virus nuclear antigen 1 interacts with Nm23-H1 in lymphoblastoid cell lines and inhibits its ability to suppress cell migration.

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Journal:  Mol Biol Cell       Date:  2004-06-11       Impact factor: 4.138

10.  Nucleotide affinity for a stable phosphorylated intermediate of nucleoside diphosphate kinase.

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Journal:  Protein Sci       Date:  2002-07       Impact factor: 6.725
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