Literature DB >> 9742937

Isolation of human intestinal defensins from ileal neobladder urine.

E M Porter1, M A Poles, J S Lee, J Naitoh, C L Bevins, T Ganz.   

Abstract

We describe the isolation of naturally occurring human intestinal defensins HD-5 and HD-6 from ileal neobladder urine and ileal mucosa. Using an antibody-based detection assay, we found multiple N-terminally processed forms of HD-5. The predominant HD-5 forms in tissue were longer than those in neobladder urine (amino acid (aa) 23-94 and 29-94 versus aa 36-94, 56-94 and 63-94) suggesting that Paneth cells store prodefensin that is processed to mature defensin during or after degranulation. Search for mature HD-6 yielded aa 69-100 as the predominant form in both sources. The ileal neobladder is a promising model to study human Paneth cell secretion.

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Year:  1998        PMID： 9742937     DOI： 10.1016/s0014-5793(98)00994-6

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  25 in total

Review 1.  Defensins and innate host defence of the gastrointestinal tract.

Authors:  C L Bevins; E Martin-Porter; T Ganz
Journal:  Gut       Date:  1999-12       Impact factor: 23.059

Review 2.  Paneth cells: their role in innate immunity and inflammatory disease.

Authors:  D A Elphick; Y R Mahida
Journal:  Gut       Date:  2005-12       Impact factor: 23.059

3.  Reduced Paneth cell alpha-defensins in ileal Crohn's disease.

Authors:  Jan Wehkamp; Nita H Salzman; Edith Porter; Sabine Nuding; Michael Weichenthal; Robert E Petras; Bo Shen; Elke Schaeffeler; Matthias Schwab; Rose Linzmeier; Ryan W Feathers; Hiutung Chu; Heriberto Lima; Klaus Fellermann; Tomas Ganz; Eduard F Stange; Charles L Bevins
Journal:  Proc Natl Acad Sci U S A       Date:  2005-12-05       Impact factor: 11.205

Review 4.  Paneth cells, antimicrobial peptides and maintenance of intestinal homeostasis.

Authors:  Charles L Bevins; Nita H Salzman
Journal:  Nat Rev Microbiol       Date:  2011-03-22       Impact factor: 60.633

Review 5.  Amplifying renal immunity: the role of antimicrobial peptides in pyelonephritis.

Authors:  Brian Becknell; Andrew Schwaderer; David S Hains; John David Spencer
Journal:  Nat Rev Nephrol       Date:  2015-07-07       Impact factor: 28.314

6.  Human defensin 5 is stored in precursor form in normal Paneth cells and is expressed by some villous epithelial cells and by metaplastic Paneth cells in the colon in inflammatory bowel disease.

Authors:  R N Cunliffe; F R Rose; J Keyte; L Abberley; W C Chan; Y R Mahida
Journal:  Gut       Date:  2001-02       Impact factor: 23.059

7.  Distinct defensin profiles in Neisseria gonorrhoeae and Chlamydia trachomatis urethritis reveal novel epithelial cell-neutrophil interactions.

Authors:  Edith Porter; Huixia Yang; Sujata Yavagal; Gloria C Preza; Omar Murillo; Heriberto Lima; Sheila Greene; Laily Mahoozi; Marcia Klein-Patel; Gill Diamond; Sunita Gulati; Tomas Ganz; Peter A Rice; Alison J Quayle
Journal:  Infect Immun       Date:  2005-08       Impact factor: 3.441

8.  Differential Processing of {alpha}- and {beta}-Defensin Precursors by Matrix Metalloproteinase-7 (MMP-7).

Authors:  Carole L Wilson; Amy P Schmidt; Emma Pirilä; Erika V Valore; Nicola Ferri; Timo Sorsa; Tomas Ganz; William C Parks
Journal:  J Biol Chem       Date:  2009-01-30       Impact factor: 5.157

9.  Microbicidal properties and cytocidal selectivity of rhesus macaque theta defensins.

Authors:  Dat Tran; Patti Tran; Kevin Roberts; George Osapay; Justin Schaal; Andre Ouellette; Michael E Selsted
Journal:  Antimicrob Agents Chemother       Date:  2007-12-26       Impact factor: 5.191

10.  Reduced mucosal antimicrobial activity in Crohn's disease of the colon.

Authors:  Sabine Nuding; Klaus Fellermann; Jan Wehkamp; Eduard F Stange
Journal:  Gut       Date:  2007-04-24       Impact factor: 23.059
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