BACKGROUND: Complications of opioid analgesia include tolerance and withdrawal. OBJECTIVES: To determine the effects of morphine and fentanyl on the prevalence of withdrawal after extracorporeal membrane oxygenation. METHODS: Two groups of neonates were compared during and after extracorporeal membrane oxygenation: a prospective group receiving a continuous infusion of morphine for analgesia and sedation and a retrospective group who had received a continuous infusion of fentanyl. RESULTS: Neonates receiving morphine required significantly less supplemental analgesia (P < .001) than did neonates who had received fentanyl and had a significantly lower prevalence of withdrawal after the therapy (P = .01). Neonates receiving morphine were discharged from the hospital a mean of 9.6 days sooner (P = .01) than neonates who had received fentanyl. CONCLUSIONS: Morphine may offer marked advantages over fentanyl for providing continuous analgesia and sedation in neonates.
BACKGROUND: Complications of opioid analgesia include tolerance and withdrawal. OBJECTIVES: To determine the effects of morphine and fentanyl on the prevalence of withdrawal after extracorporeal membrane oxygenation. METHODS: Two groups of neonates were compared during and after extracorporeal membrane oxygenation: a prospective group receiving a continuous infusion of morphine for analgesia and sedation and a retrospective group who had received a continuous infusion of fentanyl. RESULTS: Neonates receiving morphine required significantly less supplemental analgesia (P < .001) than did neonates who had received fentanyl and had a significantly lower prevalence of withdrawal after the therapy (P = .01). Neonates receiving morphine were discharged from the hospital a mean of 9.6 days sooner (P = .01) than neonates who had received fentanyl. CONCLUSIONS:Morphine may offer marked advantages over fentanyl for providing continuous analgesia and sedation in neonates.
Authors: James B Schneider; Todd Sweberg; Lisa A Asaro; Aileen Kirby; David Wypij; Ravi R Thiagarajan; Martha A Q Curley Journal: Crit Care Med Date: 2017-10 Impact factor: 7.598
Authors: D Rana; B Bellflower; J Sahni; A J Kaplan; N T Owens; E L Arrindell; A J Talati; R Dhanireddy Journal: J Perinatol Date: 2017-06-15 Impact factor: 2.521
Authors: Punkaj Gupta; Joseph D Tobias; Sunali Goyal; Jacob E Kuperstock; Sana F Hashmi; Jennifer Shin; Christopher J Hartnick; Natan Noviski Journal: Saudi J Anaesth Date: 2010-09