Literature DB >> 9740154

Identification of crystals in kidneys of AIDS patients treated with foscarnet.

L Maurice-Estepa1, M Daudon, C Katlama, C Jouanneau, V Sazdovitch, B Lacour, H Beaufils.   

Abstract

Three acquired immune deficiency syndrome patients given foscarnet to treat cytomegalovirus retinitis developed renal failure with crystal deposits within the renal glomeruli. We identified these crystals as a mixture of sodium salt, calcium salt, and a mixed salt containing both sodium and calcium ions. This composition has not been previously reported. Foscarnet can complex available ionized calcium and secondarily precipitate in glomeruli. The percentage of complexing depends on calcium concentration in serum and the poor calcium salt solubility.

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Year:  1998        PMID： 9740154     DOI： 10.1053/ajkd.1998.v32.pm9740154

Source DB:  PubMed          Journal:  Am J Kidney Dis        ISSN： 0272-6386            Impact factor:   8.860


  10 in total

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9.  Brincidofovir Use after Foscarnet Crystal Nephropathy in a Kidney Transplant Recipient with Multiresistant Cytomegalovirus Infection.

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Journal:  Case Rep Transplant       Date:  2017-02-27

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  10 in total

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