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Literature DB >> 9739758

The papillomavirus E6 proteins.

Abstract

Specific types of human papillomaviruses (HPV) are strongly associated with the development of cervical cancer. The E6 gene from cancer-related HPVs has exhibited functions in tumorigenesis, regulation of transcription, telomerase, and apoptosis. Cancer-related HPVs E6 proteins bind the tumor suppressor p53 and promotes its degradation through an ubiquitin-dependent pathway. Several additional cellular E6-binding proteins have recently been identified and implicated in playing roles in p53-independent functions of E6.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 1998 PMID： 9739758 DOI： 10.1016/s0304-419x(98)00009-2

Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002

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Cited

25 in total

1. Papillomavirus type 16 oncogenes downregulate expression of interferon-responsive genes and upregulate proliferation-associated and NF-kappaB-responsive genes in cervical keratinocytes.

Authors: M Nees; J M Geoghegan; T Hyman; S Frank; L Miller; C D Woodworth
Journal: J Virol Date: 2001-05 Impact factor: 5.103

2. Multi-PDZ domain protein MUPP1 is a cellular target for both adenovirus E4-ORF1 and high-risk papillomavirus type 18 E6 oncoproteins.

Authors: S S Lee; B Glaunsinger; F Mantovani; L Banks; R T Javier
Journal: J Virol Date: 2000-10 Impact factor: 5.103

3. Regulation of a senescence checkpoint response by the E2F1 transcription factor and p14(ARF) tumor suppressor.

Authors: G P Dimri; K Itahana; M Acosta; J Campisi
Journal: Mol Cell Biol Date: 2000-01 Impact factor: 4.272

4. Activation of Cdc2 contributes to apoptosis in HPV E6 expressing human keratinocytes in response to therapeutic agents.

Authors: Zhi-Guo Liu; Li-Na Zhao; Ying-Wang Liu; Ting-Ting Li; Dai-Ming Fan; Jason J Chen
Journal: J Mol Biol Date: 2007-09-18 Impact factor: 5.469

5. Nuclear matrix attachment regions of human papillomavirus type 16 repress or activate the E6 promoter, depending on the physical state of the viral DNA.

Authors: W Stünkel; Z Huang; S H Tan; M J O'Connor; H U Bernard
Journal: J Virol Date: 2000-03 Impact factor: 5.103

6. Nuclear import of cutaneous beta genus HPV8 E7 oncoprotein is mediated by hydrophobic interactions between its zinc-binding domain and FG nucleoporins.

Authors: Zeynep Onder; Junona Moroianu
Journal: Virology Date: 2013-12-05 Impact factor: 3.616

The papillomavirus E6 proteins.

1. Papillomavirus type 16 oncogenes downregulate expression of interferon-responsive genes and upregulate proliferation-associated and NF-kappaB-responsive genes in cervical keratinocytes.

2. Multi-PDZ domain protein MUPP1 is a cellular target for both adenovirus E4-ORF1 and high-risk papillomavirus type 18 E6 oncoproteins.

3. Regulation of a senescence checkpoint response by the E2F1 transcription factor and p14(ARF) tumor suppressor.

4. Activation of Cdc2 contributes to apoptosis in HPV E6 expressing human keratinocytes in response to therapeutic agents.

5. Nuclear matrix attachment regions of human papillomavirus type 16 repress or activate the E6 promoter, depending on the physical state of the viral DNA.

6. Nuclear import of cutaneous beta genus HPV8 E7 oncoprotein is mediated by hydrophobic interactions between its zinc-binding domain and FG nucleoporins.

7. Activation of p53 in cervical carcinoma cells by small molecules.

8. Smoking modifies the relationship between XRCC1 haplotypes and HPV16-negative head and neck squamous cell carcinoma.

9. Identification of the nuclear localization and export signals of high risk HPV16 E7 oncoprotein.

Review 10. Human telomerase and its regulation.