Literature DB >> 973934

The pharmacokinetics of ephedrine after oral dosage in asthmatics receiving acute and chronic treatment.

M E Pickup, C S May, R Ssendagire, J W Paterson.   

Abstract

1 Ephedrine plasma levels have been measured in ten asthmatic patients given a singel dose of ephedrine hydrochloride (22 mg) along and in combination with theophylline and a barbiturate. 2 Pharmacokinetic assessment of the data indicated no significant intra-subject changes in kinetic parameters before or after chronic treatment with ephedrine HCl (11 mg three times a day) alone or in combination. 3 Tolerance to these therapeutic doses, if it occurs, is therefore not disposition-related but rather to pharmacodynamic changes.

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Year:  1976        PMID： 973934      PMCID： PMC1428819          DOI： 10.1111/j.1365-2125.1976.tb00579.x

Source DB:  PubMed          Journal:  Br J Clin Pharmacol        ISSN： 0306-5251            Impact factor:   4.335


  11 in total

1.  SOME POSSIBLE ERRORS IN THE PLOTTING AND INTERPRETATION OF SEMILOGARITHMIC PLOTS OF BLOOD LEVEL AND URINARY EXCRETION DATA.

Authors:  J G WAGNER
Journal:  J Pharm Sci       Date:  1963-11       Impact factor: 3.534

2.  Ephedrine Dosage in Bronchial Asthma and Emphysema.

Authors:  H Herxheimer
Journal:  Br Med J       Date:  1946-03-09

3.  Pharmacokinetics of nortriptyline in man after single and multiple oral doses: the predictability of steady-state plasma concentrations from single-dose plasma-level data.

Authors:  B Alexanderson
Journal:  Eur J Clin Pharmacol       Date:  1972-03       Impact factor: 2.953

4.  Influence of route of administration on drug availability.

Authors:  M Rowland
Journal:  J Pharm Sci       Date:  1972-01       Impact factor: 3.534

5.  Absorption metabolism and excretion of the ephedrines in man. I. The influence of urinary pH and urine volume output.

Authors:  G R Wilkinson; A H Beckett
Journal:  J Pharmacol Exp Ther       Date:  1968-07       Impact factor: 4.030

6.  Absorption, metabolism, and excretion of the ephedrines in man. II. Pharmacokinetics.

Authors:  G R Wilkinson; A H Beckett
Journal:  J Pharm Sci       Date:  1968-11       Impact factor: 3.534

7.  Influence of first-pass effect on availability of drugs on oral administration.

Authors:  M Gibaldi; R N Boyes; S Feldman
Journal:  J Pharm Sci       Date:  1971-09       Impact factor: 3.534

8.  The acute and chronic bronchodilator effects of ephedrine in asthmatic patients.

Authors:  C S May; M E Pickup; J W Paterson
Journal:  Br J Clin Pharmacol       Date:  1975-12       Impact factor: 4.335

9.  Blood levels of drug at the equilibrium state after multiple dosing.

Authors:  J G Wagner; J I Northam; C D Alway; O S Carpenter
Journal:  Nature       Date:  1965-09-18       Impact factor: 49.962

10.  Urinary excretion of ephedrine in man without pH control following oral administration of three commercial ephedrine sulfate preparations.

Authors:  P G Welling; K P Lee; J A Patel; J E Walker; J G Wagner
Journal:  J Pharm Sci       Date:  1971-11       Impact factor: 3.534
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  5 in total

1.  The absorption and elimination of ICI 74,917 in man.

Authors:  M E Pickup; A J Johnson; C S May; J W Paterson; M P Harrison
Journal:  Br J Clin Pharmacol       Date:  1977-06       Impact factor: 4.335

Review 2.  Pulmonary disease and drug kinetics.

Authors:  P du Souich; A J McLean; D Lalka; S Erill; M Gibaldi
Journal:  Clin Pharmacokinet       Date:  1978 Jul-Aug       Impact factor: 6.447

3.  Modelling the cardiovascular effects of ephedrine.

Authors:  Adam M Persky; N Seth Berry; Gary M Pollack; Kim L R Brouwer
Journal:  Br J Clin Pharmacol       Date:  2004-05       Impact factor: 4.335

4.  Mechanistic pharmacokinetic modelling of ephedrine, norephedrine and caffeine in healthy subjects.

Authors:  C Csajka; C A Haller; N L Benowitz; D Verotta
Journal:  Br J Clin Pharmacol       Date:  2005-03       Impact factor: 4.335

5.  A Pharmacokinetic Study of Ephedrine and Pseudoephedrine after Oral Administration of Ojeok-San by Validated LC-MS/MS Method in Human Plasma.

Authors:  Sooyoung Lee; Wang-Seob Shim; Heejo Yoo; Sanghee Choi; Jiyoung Yoon; Kwang-Young Lee; Eun-Kyoung Chung; Byung-Cheol Lee; Sung-Vin Yim; Bo-Hyung Kim; Kyung-Tae Lee
Journal:  Molecules       Date:  2021-11-19       Impact factor: 4.411
  5 in total

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