Literature DB >> 9738976

Molecular analysis of Ewing's sarcoma: another fusion gene, EWS-E1AF, available for diagnosis.

F Urano1, A Umezawa, H Yabe, W Hong, K Yoshida, K Fujinaga, J Hata.   

Abstract

Ewing's sarcoma, one of the most malignant tumors of children and young adults, expresses specific chimeric genes, e.g. EWS-FLI-1, EWS-ERG, EWS-ETV1 and EWS-FEV. In this paper, we extensively characterized a new fusion gene, EWS-EIAF by means of whole cDNA sequencing, RNA blot analysis, DNA blot analysis and chromosomal analysis, and showed it to be available for the diagnosis of Ewing's sarcoma and to participate in the oncogenesis of Ewing's sarcoma. Furthermore, we conducted a genetic analysis of Ewing family tumors in conjunction with immunohistochemical analysis and ultrastructural analysis. Our results demonstrate some limitations of both genetic analysis and histopathological analysis, and establish the relationship between neurogenic phenotypes and chimera genes.

Entities:  

Mesh：

Substances：

Year:  1998        PMID： 9738976      PMCID： PMC5921883          DOI： 10.1111/j.1349-7006.1998.tb03274.x

Source DB:  PubMed          Journal:  Jpn J Cancer Res        ISSN： 0910-5050


  29 in total

1.  Interaction of murine ets-1 with GGA-binding sites establishes the ETS domain as a new DNA-binding motif.

Authors:  J A Nye; J M Petersen; C V Gunther; M D Jonsen; B J Graves
Journal:  Genes Dev       Date:  1992-06       Impact factor: 11.361

2.  Neurogenic potential of Ewing's sarcoma cells.

Authors:  T Sugimoto; A Umezawa; J Hata
Journal:  Virchows Arch       Date:  1997-01       Impact factor: 4.064

3.  A variant Ewing's sarcoma translocation (7;22) fuses the EWS gene to the ETS gene ETV1.

Authors:  I S Jeon; J N Davis; B S Braun; J E Sublett; M F Roussel; C T Denny; D N Shapiro
Journal:  Oncogene       Date:  1995-03-16       Impact factor: 9.867

4.  EWS/Fli-1 chimeric protein is a transcriptional activator.

Authors:  T Ohno; V N Rao; E S Reddy
Journal:  Cancer Res       Date:  1993-12-15       Impact factor: 12.701

5.  High-affinity DNA-protein interactions of the cellular ETS1 protein: the determination of the ETS binding motif.

Authors:  R J Fisher; G Mavrothalassitis; A Kondoh; T S Papas
Journal:  Oncogene       Date:  1991-12       Impact factor: 9.867

6.  Fusion of an ETS-family gene, EIAF, to EWS by t(17;22)(q12;q12) chromosome translocation in an undifferentiated sarcoma of infancy.

Authors:  Y Kaneko; K Yoshida; M Handa; Y Toyoda; H Nishihira; Y Tanaka; Y Sasaki; S Ishida; F Higashino; K Fujinaga
Journal:  Genes Chromosomes Cancer       Date:  1996-02       Impact factor: 5.006

7.  The genomic breakpoint and chimeric transcripts in the EWSR1-ETV4/E1AF gene fusion in Ewing sarcoma.

Authors:  S Ishida; K Yoshida; Y Kaneko; Y Tanaka; Y Sasaki; F Urano; A Umezawa; J Hata; K Fujinaga
Journal:  Cytogenet Cell Genet       Date:  1998

8.  A novel effector domain from the RNA-binding protein TLS or EWS is required for oncogenic transformation by CHOP.

Authors:  H Zinszner; R Albalat; D Ron
Journal:  Genes Dev       Date:  1994-11-01       Impact factor: 11.361

9.  The c-Ets oncoprotein activates the stromelysin promoter through the same elements as several non-nuclear oncoproteins.

Authors:  C Wasylyk; A Gutman; R Nicholson; B Wasylyk
Journal:  EMBO J       Date:  1991-05       Impact factor: 11.598

10.  A monoclonal antibody specifically reactive with Ewing's sarcoma.

Authors:  S Hara; E Ishii; S Tanaka; J Yokoyama; K Katsumata; J Fujimoto; J Hata
Journal:  Br J Cancer       Date:  1989-12       Impact factor: 7.640
View more
  12 in total

1.  Molecular Approaches to Diagnosis in Ewing Sarcoma: Fluorescence In Situ Hybridization (FISH).

Authors:  Marcel Trautmann; Wolfgang Hartmann
Journal:  Methods Mol Biol       Date:  2021

2.  Molecular diagnosis in Ewing family tumors: the Rizzoli experience--222 consecutive cases in four years.

Authors:  Gabriella Gamberi; Stefania Cocchi; Stefania Benini; Giovanna Magagnoli; Luca Morandi; Jennifer Kreshak; Marco Gambarotti; Piero Picci; Licciana Zanella; Marco Alberghini
Journal:  J Mol Diagn       Date:  2011-03-31       Impact factor: 5.568

3.  EWSR1 fusion proteins mediate PAX7 expression in Ewing sarcoma.

Authors:  Gregory W Charville; Wei-Lien Wang; Davis R Ingram; Angshumoy Roy; Dafydd Thomas; Rajiv M Patel; Jason L Hornick; Matt van de Rijn; Alexander J Lazar
Journal:  Mod Pathol       Date:  2017-06-23       Impact factor: 7.842

4.  Identification of a novel translocation producing an in-frame fusion of TAF15 and ETV4 in a case of extraosseous Ewing sarcoma revealed in the prenatal period.

Authors:  Cécile Picard; Nicolas Macagno; Nadège Corradini; Perrine Marec-Bérard; Sara Cabet; Laurent Guibaud; Loic Viremouneix; Sébastien Raux; Franck Chotel; Nicolas Weinbreck; Alexandra Meurgey; Marie Karanian; Daniel Pissaloux; Frank Tirode; Frédérique Dijoud
Journal:  Virchows Arch       Date:  2022-05-09       Impact factor: 4.535

5.  Clinicopathological and molecular spectrum of ewing sarcomas/PNETs, including validation of EWSR1 rearrangement by conventional and array FISH technique in certain cases.

Authors:  Bharat Rekhi; Ulrich Vogel; Ranjan Basak; Sangeeta B Desai; Nirmala A Jambhekar
Journal:  Pathol Oncol Res       Date:  2013-11-30       Impact factor: 3.201

Review 6.  3D tissue-engineered model of Ewing's sarcoma.

Authors:  Salah-Eddine Lamhamedi-Cherradi; Marco Santoro; Vandhana Ramammoorthy; Brian A Menegaz; Geoffrey Bartholomeusz; Lakesla R Iles; Hesham M Amin; J Andrew Livingston; Antonios G Mikos; Joseph A Ludwig
Journal:  Adv Drug Deliv Rev       Date:  2014-08-07       Impact factor: 15.470

7.  Ewing sarcoma with novel translocation t(2;16) producing an in-frame fusion of FUS and FEV.

Authors:  Tony L Ng; Maureen J O'Sullivan; Catherine J Pallen; Malcolm Hayes; Paul W Clarkson; Mark Winstanley; Poul H B Sorensen; Torsten O Nielsen; Douglas E Horsman
Journal:  J Mol Diagn       Date:  2007-07-09       Impact factor: 5.568

8.  Undifferentiated small round cell sarcomas with rare EWS gene fusions: identification of a novel EWS-SP3 fusion and of additional cases with the EWS-ETV1 and EWS-FEV fusions.

Authors:  Lu Wang; Rohit Bhargava; Tao Zheng; Leonard Wexler; Margaret H Collins; Diane Roulston; Marc Ladanyi
Journal:  J Mol Diagn       Date:  2007-08-09       Impact factor: 5.568

9.  Ewing sarcoma of the liver with multilocular cystic mass formation: a case report.

Authors:  Yukinori Ozaki; Yuji Miura; Shigehiro Koganemaru; Koichi Suyama; Naoko Inoshita; Takeshi Fujii; Masaji Hashimoto; Tetsuo Tamura; Kazuo Takeuchi; Toshimi Takano
Journal:  BMC Cancer       Date:  2015-01-22       Impact factor: 4.430

10.  Metastatic extraskeletal Ewing's sarcoma treated with trabectedin: A case report.

Authors:  Jorge Hernando-Cubero; Pilar Sanz-Moncasi; Alba Hernández-García; Isabel Pajares-Bernard; Javier Martínez-Trufero
Journal:  Oncol Lett       Date:  2016-08-03       Impact factor: 2.967
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.