Literature DB >> 9738950

cDNA cloning and inducible expression of human multidrug resistance associated protein 3 (MRP3).

Y Kiuchi1, H Suzuki, T Hirohashi, C A Tyson, Y Sugiyama.   

Abstract

Previously, we cloned rat MRP3 as a candidate for an inducible transporter for the biliary excretion of organic anions [Hirohashi et al. (1998) Mol. Pharmacol. 53, 1068-10751. In the present study, we cloned human MRP3 (1527 amino acids) from Caco-2 cells. Human MRP3 is predominantly expressed in liver, small intestine and colon; hepatic expression of MRP3 was observed in humans but not in normal rats. In HepG2 cells, the expression of MRP3 was induced by phenobarbital. These results suggest that MRP3 may act as an inducible transporter in the biliary and intestinal excretion of organic anions.

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Year:  1998        PMID： 9738950     DOI： 10.1016/s0014-5793(98)00899-0

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  27 in total

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