R B Tate1, J Manfreda, T E Cuddy. 1. Department of Community Health Sciences, University of Manitoba, Winnipeg, Canada.
Abstract
PURPOSE: The purpose of this paper is to determine the age-specific relationships between risk factors at age 40 through 75 years and ischemic heart disease (IHD), and to determine the effects of aging on these relationships in a cohort of 3983 Canadian males. METHODS: The Manitoba Follow-Up Study is the prospective investigation of cardiovascular disease as it develops in a cohort of 3983 young men. Over a period of 45 years, from 1948 to 1993, 1094 study members (27%) developed clinical evidence of IHD. Blood pressure, body weight, smoking, and presence of diabetes mellitus have been recorded at regular intervals throughout the follow-up period. Using measurements from examinations every 5 years between ages 40 and 75 years, age-specific Cox proportional hazard models were fit to relate these risk factors to IHD. RESULTS: The adjusted relative risk of IHD for systolic blood pressure, diastolic blood pressure and smoking were found to significantly (p < 0.001) decline with advancing age. The adjusted relative risk for body mass index and presence of diabetes mellitus for ischemic heart disease did not vary with age (p > 0.05). After age 65 years, these risk factors were of little value for the prediction of IHD. CONCLUSIONS: The relative risk and statistical significance of blood pressure and smoking, as risk factors for IHD, decline with age.
PURPOSE: The purpose of this paper is to determine the age-specific relationships between risk factors at age 40 through 75 years and ischemic heart disease (IHD), and to determine the effects of aging on these relationships in a cohort of 3983 Canadian males. METHODS: The Manitoba Follow-Up Study is the prospective investigation of cardiovascular disease as it develops in a cohort of 3983 young men. Over a period of 45 years, from 1948 to 1993, 1094 study members (27%) developed clinical evidence of IHD. Blood pressure, body weight, smoking, and presence of diabetes mellitus have been recorded at regular intervals throughout the follow-up period. Using measurements from examinations every 5 years between ages 40 and 75 years, age-specific Cox proportional hazard models were fit to relate these risk factors to IHD. RESULTS: The adjusted relative risk of IHD for systolic blood pressure, diastolic blood pressure and smoking were found to significantly (p < 0.001) decline with advancing age. The adjusted relative risk for body mass index and presence of diabetes mellitus for ischemic heart disease did not vary with age (p > 0.05). After age 65 years, these risk factors were of little value for the prediction of IHD. CONCLUSIONS: The relative risk and statistical significance of blood pressure and smoking, as risk factors for IHD, decline with age.
Authors: Teresa E Seeman; Dana M Miller-Martinez; Sharon Stein Merkin; Margie E Lachman; Patricia A Tun; Arun S Karlamangla Journal: J Gerontol B Psychol Sci Soc Sci Date: 2010-12-31 Impact factor: 4.077
Authors: Astrid D Häberle; Mary L Biggs; Mary Cushman; Bruce M Psaty; Anne B Newman; Michael G Shlipak; John Gottdiener; Chenkai Wu; Julius M Gardin; Nisha Bansal; Michelle C Odden Journal: J Gerontol A Biol Sci Med Sci Date: 2021-02-25 Impact factor: 6.053
Authors: Yang Hu; Jeffrey A Sparks; Susan Malspeis; Karen H Costenbader; Frank B Hu; Elizabeth W Karlson; Bing Lu Journal: Ann Rheum Dis Date: 2017-01-30 Impact factor: 19.103
Authors: Gitanjali M Singh; Goodarz Danaei; Pamela M Pelizzari; John K Lin; Melanie J Cowan; Gretchen A Stevens; Farshad Farzadfar; Young-Ho Khang; Yuan Lu; Leanne M Riley; Stephen S Lim; Majid Ezzati Journal: Circulation Date: 2012-04-04 Impact factor: 29.690
Authors: Michelle C Odden; Michael G Shlipak; Heather E Whitson; Ronit Katz; Patricia M Kearney; Chris defilippi; Shani Shastri; Mark J Sarnak; David S Siscovick; Mary Cushman; Bruce M Psaty; Anne B Newman Journal: Atherosclerosis Date: 2014-09-30 Impact factor: 5.162
Authors: Aline Milane; Jad Abdallah; Roy Kanbar; Georges Khazen; Michella Ghassibe-Sabbagh; Angelique K Salloum; Sonia Youhanna; Aline Saad; Hamid El Bayeh; Elie Chammas; Daniel E Platt; Jörg Hager; Dominique Gauguier; Pierre Zalloua; Antoine Abchee Journal: Springerplus Date: 2014-09-16