PURPOSE: Management of chemotherapy-induced diarrhea (CID) has customarily involved symptomatic treatment with opioids in conjunction with supportive care. Alternatively, patients refractory to conventional therapy have been given octreotide, a somatostatin analogue. Although this agent has been effective against CID, no widely accepted treatment guidelines that incorporate its use currently exist. An expert multidisciplinary panel was convened to formulate clinical practice guidelines for the treatment of CID. METHODS: The panel reviewed clinical data on the management of CID reported in the literature and analyzed currently available tools used to assess CID. Expert consensus was applied when published data were insufficient. Panel members also considered the effect of CID on quality of life and the cost-effectiveness and efficacy of different pharmacologic approaches. Effective resolution of CID and decreases in the need for supportive care or hospitalization were considered to be primary goals in the formulation of the guidelines. RESULTS: The panel formulated suggested practice guidelines for the management of CID that detail recommendations for the assessment and evaluation of diarrhea and the sequence and duration of administration of specific pharmacologic agents. CONCLUSION: The consensus of the panel was that standardized assessment and management of diarrhea is required to effectively control CID. The panel agreed that further data from a National Cancer Institute (NCI)-sponsored intergroup trial is required to determine the optimal dosage of octreotide and its cost in the treatment of cancer. The panel also agreed that further clinical research is warranted to address significant questions about the most effective way to assess and treat CID.
PURPOSE: Management of chemotherapy-induced diarrhea (CID) has customarily involved symptomatic treatment with opioids in conjunction with supportive care. Alternatively, patients refractory to conventional therapy have been given octreotide, a somatostatin analogue. Although this agent has been effective against CID, no widely accepted treatment guidelines that incorporate its use currently exist. An expert multidisciplinary panel was convened to formulate clinical practice guidelines for the treatment of CID. METHODS: The panel reviewed clinical data on the management of CID reported in the literature and analyzed currently available tools used to assess CID. Expert consensus was applied when published data were insufficient. Panel members also considered the effect of CID on quality of life and the cost-effectiveness and efficacy of different pharmacologic approaches. Effective resolution of CID and decreases in the need for supportive care or hospitalization were considered to be primary goals in the formulation of the guidelines. RESULTS: The panel formulated suggested practice guidelines for the management of CID that detail recommendations for the assessment and evaluation of diarrhea and the sequence and duration of administration of specific pharmacologic agents. CONCLUSION: The consensus of the panel was that standardized assessment and management of diarrhea is required to effectively control CID. The panel agreed that further data from a National Cancer Institute (NCI)-sponsored intergroup trial is required to determine the optimal dosage of octreotide and its cost in the treatment of cancer. The panel also agreed that further clinical research is warranted to address significant questions about the most effective way to assess and treat CID.
Authors: Babu Zachariah; Clement K Gwede; Jennifer James; Jaffer Ajani; Lisa J Chin; David Donath; Seth A Rosenthal; Brent L Kane; Marvin Rotman; Lawrence Berk; Lisa A Kachnic Journal: J Natl Cancer Inst Date: 2010-03-25 Impact factor: 13.506
Authors: Nicholas Dainiak; Robert Nicolas Gent; Zhanat Carr; Rita Schneider; Judith Bader; Elena Buglova; Nelson Chao; C Norman Coleman; Arnold Ganser; Claude Gorin; Martin Hauer-Jensen; L Andrew Huff; Patricia Lillis-Hearne; Kazuhiko Maekawa; Jeffrey Nemhauser; Ray Powles; Holger Schünemann; Alla Shapiro; Leif Stenke; Nelson Valverde; David Weinstock; Douglas White; Joseph Albanese; Viktor Meineke Journal: Disaster Med Public Health Prep Date: 2011-10-10 Impact factor: 1.385
Authors: J Cassinello; P López-Alvarez; A Martínez-Guisado; M Valladares; G Huidobro; R López; U Bohn; I Sevilla; P Ballesteros; M Jorge; R Pérez-Carrión; J L Fernández; J Dorta Journal: Med Oncol Date: 2003 Impact factor: 3.064
Authors: M Yasuda; S Kato; N Yamanaka; M Iimori; K Matsumoto; D Utsumi; Y Kitahara; K Amagase; S Horie; K Takeuchi Journal: Br J Pharmacol Date: 2013-03 Impact factor: 8.739
Authors: James A Martenson; Michele Y Halyard; Jeff A Sloan; Gary M Proulx; Robert C Miller; Richard L Deming; Stephen J Dick; Harold A Johnson; T H Patricia Tai; Angela W Zhu; Joan Keit; Kathy J Stien; Pamela J Atherton Journal: J Clin Oncol Date: 2008-09-02 Impact factor: 44.544