| Literature DB >> 9738473 |
T Occhiodoro1, L Bernheim, J H Liu, P Bijlenga, M Sinnreich, C R Bader, J Fischer-Lougheed.
Abstract
An early sign of human myoblast commitment to fusion is the expression of a non-inactivating delayed rectifier K+ current, I(K(NI)), and an associated membrane potential hyperpolarization. We have isolated the full-length coding region of a human ether-a-go-go K+ channel (h-eag) from myoblasts undergoing differentiation. The h-eag gene was localized to chromosome 1q32-41, and is expressed as a approximately 9 kb transcript in myogenic cells and in adult brain tissue. Forced expression of h-eag in undifferentiated myoblasts generates a current with remarkable similarity to I(K(NI)) indicating that h-eag constitutes the channel responsible for this current in vivo.Entities:
Mesh：
Substances：
Year: 1998 PMID： 9738473 DOI： 10.1016/s0014-5793(98)00973-9
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124