Literature DB >> 9737674

Immunocytochemical localization of inducible nitric oxide synthase and transforming growth factor-beta (TGF-beta) in leprosy lesions.

S Khanolkar-Young1, D Snowdon, D N Lockwood.   

Abstract

Inducible nitric oxide synthase (iNOS) and TGF-beta were localized by immunocytochemistry in skin lesions from patients across the leprosy spectrum, and from patients undergoing reversal reaction. iNOS expression was highest at the tuberculoid pole of the spectrum, and increased during reversal reaction. TGF-beta was observed throughout the leprosy spectrum, but was highest at the lepromatous pole. Levels of TGF-beta decreased during reversal reaction. Reduced levels of TGF-beta may contribute to unregulated inflammatory responses during reactional episodes.

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Year:  1998        PMID： 9737674      PMCID： PMC1905052          DOI： 10.1046/j.1365-2249.1998.00669.x

Source DB:  PubMed          Journal:  Clin Exp Immunol        ISSN： 0009-9104            Impact factor:   4.330


  23 in total

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Journal:  Int J Lepr Other Mycobact Dis       Date:  1966 Jul-Sep

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Journal:  Int J Lepr Other Mycobact Dis       Date:  1985-09

6.  The outpatient treatment of nerve damage in patients with borderline leprosy using a semi-standardized steroid regimen.

Authors:  K U Kiran; J N Stanley; J M Pearson
Journal:  Lepr Rev       Date:  1985-06       Impact factor: 0.537

7.  The inducing role of tumor necrosis factor in the development of bactericidal granulomas during BCG infection.

Authors:  V Kindler; A P Sappino; G E Grau; P F Piguet; P Vassalli
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8.  Macrophage production of transforming growth factor beta and fibroblast collagen synthesis in chronic pulmonary inflammation.

Authors:  N Khalil; O Bereznay; M Sporn; A H Greenberg
Journal:  J Exp Med       Date:  1989-09-01       Impact factor: 14.307

9.  Analysis of naturally occurring delayed-type hypersensitivity reactions in leprosy by in situ hybridization.

Authors:  C L Cooper; C Mueller; T A Sinchaisri; C Pirmez; J Chan; G Kaplan; S M Young; I L Weissman; B R Bloom; T H Rea; R L Modlin
Journal:  J Exp Med       Date:  1989-05-01       Impact factor: 14.307

10.  Platelet-derived growth factor and transforming growth factor-beta enhance tissue repair activities by unique mechanisms.

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  10 in total

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2.  Immunohistochemical analysis of cellular infiltrate and gamma interferon, interleukin-12, and inducible nitric oxide synthase expression in leprosy type 1 (reversal) reactions before and during prednisolone treatment.

Authors:  D Little; S Khanolkar-Young; A Coulthart; S Suneetha; D N Lockwood
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3.  Effects of prednisolone treatment on cytokine expression in patients with leprosy type 1 reactions.

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Review 4.  The continuing challenges of leprosy.

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6.  TGF-β-mediated sustained ERK1/2 activity promotes the inhibition of intracellular growth of Mycobacterium avium in epithelioid cells surrogates.

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7.  Cytokine and protein markers of leprosy reactions in skin and nerves: baseline results for the North Indian INFIR cohort.

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8.  Unbalanced inflammatory reaction could increase tissue destruction and worsen skin infectious diseases - a comparative study of leishmaniasis and sporotrichosis.

Authors:  F N Morgado; L M V de Carvalho; J Leite-Silva; A J Seba; M I F Pimentel; A Fagundes; M F Madeira; M R Lyra; M M Oliveira; A O Schubach; F Conceição-Silva
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9.  Clinical oxidative stress during leprosy multidrug therapy: impact of dapsone oxidation.

Authors:  Taysa Ribeiro Schalcher; Rosivaldo S Borges; Michael D Coleman; João Batista Júnior; Claudio G Salgado; Jose Luiz F Vieira; Pedro R T Romão; Fabio R Oliveira; Marta Chagas Monteiro
Journal:  PLoS One       Date:  2014-01-22       Impact factor: 3.240

10.  Is CXCL10/CXCR3 axis overexpression a better indicator of leprosy type 1 reaction than inducible nitric oxide synthase?

Authors:  Ira Sharma; Avninder Singh; Ashwani K Mishra; L C Singh; V Ramesh; Sunita Saxena
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  10 in total

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