BACKGROUND: Periodontal disease has been shown to be associated with increased risk of coronary heart disease. Because coronary heart disease and peripheral vascular disease (PVD) have similar pathophysiologies, we hypothesized that periodontal disease might be a risk factor for PVD. METHODS: Using the combined data from the Normative Aging Study and Dental Longitudinal Study of the US Department of Veterans Affairs, we examined the relationship between PVD and periodontal disease. Multivariate logistic regression analysis was used. RESULTS: Over the 25 to 30 years of follow-up, 80 of these initially healthy subjects developed PVD. Compared with controls (n = 1,030), subjects with clinically significant periodontal disease at baseline had a 2.27 increment in the risk of developing PVD (95% confidence interval 1.32 to 3.9, P value = 0.003). CONCLUSIONS: Periodontal disease emerged as a significant independent risk factor for PVD in a multivariate analysis that adjusted for other established risk factors.
BACKGROUND:Periodontal disease has been shown to be associated with increased risk of coronary heart disease. Because coronary heart disease and peripheral vascular disease (PVD) have similar pathophysiologies, we hypothesized that periodontal disease might be a risk factor for PVD. METHODS: Using the combined data from the Normative Aging Study and Dental Longitudinal Study of the US Department of Veterans Affairs, we examined the relationship between PVD and periodontal disease. Multivariate logistic regression analysis was used. RESULTS: Over the 25 to 30 years of follow-up, 80 of these initially healthy subjects developed PVD. Compared with controls (n = 1,030), subjects with clinically significant periodontal disease at baseline had a 2.27 increment in the risk of developing PVD (95% confidence interval 1.32 to 3.9, P value = 0.003). CONCLUSIONS:Periodontal disease emerged as a significant independent risk factor for PVD in a multivariate analysis that adjusted for other established risk factors.
Authors: Lubaina T Arsiwala; Yejin Mok; Chao Yang; Junichi Ishigami; Elizabeth Selvin; James D Beck; Matthew A Allison; Gerardo Heiss; Ryan T Demmer; Kunihiro Matsushita Journal: J Periodontol Date: 2021-11-17 Impact factor: 4.494
Authors: Nicole Jacobi; Carolin Walther; Katrin Borof; Guido Heydecke; Udo Seedorf; Ragna Lamprecht; Thomas Beikler; Sebastian E Debus; Christoph Waldeyer; Stefan Blankenberg; Renate B Schnabel; Ghazal Aarabi; Christian-Alexander Behrendt Journal: J Clin Med Date: 2021-05-11 Impact factor: 4.241