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Literature DB >> 9736926

Antisense therapeutics.

Abstract

The field of antisense therapeutics has attracted great interest during the past decade. A large body of literature has recently appeared in which the antisense mechanism is claimed to be involved and a number of human clinical trials are underway. Questions regarding the specificity of action and side effects of antisense phosphorothioate oligonucleotides have arisen simultaneously.

Entities: Chemical Species

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Year: 1998 PMID： 9736926 DOI： 10.1016/s1367-5931(98)80129-4

Source DB: PubMed Journal: Curr Opin Chem Biol ISSN： 1367-5931 Impact factor: 8.822

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Cited

38 in total

1. Establishment of a chemical synthetic lethality screen in cultured human cells.

Authors: A Simons; N Dafni; I Dotan; Y Oron; D Canaani
Journal: Genome Res Date: 2001-02 Impact factor: 9.043

Review 2. Chemical genetics: ligand-based discovery of gene function.

Authors: B R Stockwell
Journal: Nat Rev Genet Date: 2000-11 Impact factor: 53.242

3. Potent and nontoxic antisense oligonucleotides containing locked nucleic acids.

Authors: C Wahlestedt; P Salmi; L Good; J Kela; T Johnsson; T Hökfelt; C Broberger; F Porreca; J Lai; K Ren; M Ossipov; A Koshkin; N Jakobsen; J Skouv; H Oerum; M H Jacobsen; J Wengel
Journal: Proc Natl Acad Sci U S A Date: 2000-05-09 Impact factor: 11.205

10. Synthesis, thermal stability and resistance to enzymatic hydrolysis of the oligonucleotides containing 5-(N-aminohexyl)carbamoyl-2'-O-methyluridines.

Authors: Takanori Ito; Yoshihito Ueno; Yasuo Komatsu; Akira Matsuda
Journal: Nucleic Acids Res Date: 2003-05-15 Impact factor: 16.971

Antisense therapeutics.

1. Establishment of a chemical synthetic lethality screen in cultured human cells.

Review 2. Chemical genetics: ligand-based discovery of gene function.

3. Potent and nontoxic antisense oligonucleotides containing locked nucleic acids.

4. The spherulites(TM): a promising carrier for oligonucleotide delivery.

Review 5. The impact of molecular medicine upon early cardiovascular drug development.

6. Amelioration of dextran sulfate sodium-induced colitis by neuropeptide Y antisense oligodeoxynucleotide.

7. Radiolabeled oligonucleotides for antisense imaging.

8. Synthesis, properties, and applications of oligonucleotides containing an RNA dinucleotide phosphorothiolate linkage.

9. Identification, purification and partial characterisation of an oligonucleotide receptor in membranes of HepG2 cells.

10. Synthesis, thermal stability and resistance to enzymatic hydrolysis of the oligonucleotides containing 5-(N-aminohexyl)carbamoyl-2'-O-methyluridines.