Literature DB >> 9736538

New trimethoprim-resistant dihydrofolate reductase cassette, dfrXV, inserted in a class 1 integron.

P V Adrian1, M DU Plessis, K P Klugman, S G Amyes.   

Abstract

The nucleotide sequence of a plasmid-borne trimethoprim resistance gene from a commensal fecal Escherichia coli isolate revealed a new dihydrofolate reductase gene, dfrXV, which occurred as a gene cassette integrated in a site-specific manner in a class 1 integron. The new gene shows 84% nucleotide identity and the predicted protein shows 90% amino acid identity with dfrI and DHFR type I, respectively. Genes for spectinomycin resistance, aadA1 [ant (3")-Ia], and sulfonamide resistance, sulI, were located downstream of dfrXV in a manner identical to that in pLMO229.

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Year:  1998        PMID： 9736538      PMCID： PMC105785     

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  29 in total

1.  Enzymatic reduction of dihydrofolic acid.

Authors:  M J OSBORN; F M HUENNEKENS
Journal:  J Biol Chem       Date:  1958-10       Impact factor: 5.157

2.  The purification and properties of the trimethoprim-resistant dihydrofolate reductase mediated by the R-factor, R388.

Authors:  S G Amyes; J T Smith
Journal:  Eur J Biochem       Date:  1976-01-15

3.  R-factor trimethoprim resistance mechanism: an insusceptible target site.

Authors:  S G Amyes; J T Smith
Journal:  Biochem Biophys Res Commun       Date:  1974-05-20       Impact factor: 3.575

Review 4.  Trimethoprim and sulfonamide resistance.

Authors:  P Huovinen; L Sundström; G Swedberg; O Sköld
Journal:  Antimicrob Agents Chemother       Date:  1995-02       Impact factor: 5.191

Review 5.  Gene cassettes: a new class of mobile element.

Authors:  G D Recchia; R M Hall
Journal:  Microbiology       Date:  1995-12       Impact factor: 2.777

6.  Nucleotide sequence and genetic analysis of the type Ib trimethoprim-resistant, Tn4132-encoded dihydrofolate reductase.

Authors:  H K Young; M J Qumsieh; M L McIntosh
Journal:  J Antimicrob Chemother       Date:  1994-11       Impact factor: 5.790

7.  Diversity and relative strength of tandem promoters for the antibiotic-resistance genes of several integrons.

Authors:  C Lévesque; S Brassard; J Lapointe; P H Roy
Journal:  Gene       Date:  1994-05-03       Impact factor: 3.688

8.  Site-specific insertion of gene cassettes into integrons.

Authors:  C M Collis; G Grammaticopoulos; J Briton; H W Stokes; R M Hall
Journal:  Mol Microbiol       Date:  1993-07       Impact factor: 3.501

9.  Prevalence and genetic location of non-transferable trimethoprim resistant dihydrofolate reductase genes in South African commensal faecal isolates.

Authors:  P V Adrian; C J Thomson; K P Klugman; S G Amyes
Journal:  Epidemiol Infect       Date:  1995-10       Impact factor: 2.451

10.  Prevalence of trimethoprim resistant dihydrofolate reductase genes identified with oligonucleotide probes in plasmids from isolates of commensal faecal flora.

Authors:  P V Adrian; K P Klugman; S G Amyes
Journal:  J Antimicrob Chemother       Date:  1995-04       Impact factor: 5.790
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  4 in total

1.  Biochemical sequence analyses of GES-1, a novel class A extended-spectrum beta-lactamase, and the class 1 integron In52 from Klebsiella pneumoniae.

Authors:  L Poirel; I Le Thomas; T Naas; A Karim; P Nordmann
Journal:  Antimicrob Agents Chemother       Date:  2000-03       Impact factor: 5.191

2.  New gene cassettes for trimethoprim resistance, dfr13, and Streptomycin-spectinomycin resistance, aadA4, inserted on a class 1 integron.

Authors:  P V Adrian; C J Thomson; K P Klugman; S G Amyes
Journal:  Antimicrob Agents Chemother       Date:  2000-02       Impact factor: 5.191

3.  Distribution and content of class 1 integrons in different Vibrio cholerae O-serotype strains isolated in Thailand.

Authors:  A Dalsgaard; A Forslund; O Serichantalergs; D Sandvang
Journal:  Antimicrob Agents Chemother       Date:  2000-05       Impact factor: 5.191

4.  Adaptive resistance to biocides in Salmonella enterica and Escherichia coli O157 and cross-resistance to antimicrobial agents.

Authors:  M Braoudaki; A C Hilton
Journal:  J Clin Microbiol       Date:  2004-01       Impact factor: 5.948
  4 in total

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