OBJECTIVE: To evaluate efficacy of a combination of praziquantel, pyrantel pamoate, and febantel at 2 dosages for treating naturally acquired giardiasis in dogs. ANIMALS: 6 male and 9 female Beagles. PROCEDURE: Dogs were identified as naturally infected with Giardia sp, using the zinc sulfate concentration technique (ZSCT), and were allocated to 1 of 3 groups. Group-1 dogs were treated orally with a praziquantel (5.4 to 7 mg/kg of body weight), pyrantel pamoate (26.8 to 35.2 mg/kg), and febantel (26.8 to 35.2 mg/kg) combination, every 24 hours for 3 doses. Group-2 dogs were treated with the combination once. Group-3 dogs were nontreated controls. Four fecal samples were examined, using the ZSCT, from each dog of each group within 6 days of the last treatment. Dogs were considered to have giardiasis if 1 or more of the fecal samples had positive results for Giardia cysts. Dogs were examined daily for at least 10 days after the last treatment. RESULTS: Giardia cysts were not detected in the feces of any group-1 dog or in the feces of 2 of 5 group-2 dogs. Cysts were detected in the feces of 5 of 5 group-3 (nontreated control) dogs. Signs of toxicosis were not observed in any dog. CONCLUSION AND CLINICAL RELEVANCE: The current labeled dose (for treatment of various nematodes and cestodes, but not Giardia sp) of the combination given orally once reduces cyst excretion in Giardia-infected dogs, and should be considered for treatment of dogs shedding Giardia cysts, whether or not they have clinical signs of infection.
OBJECTIVE: To evaluate efficacy of a combination of praziquantel, pyrantel pamoate, and febantel at 2 dosages for treating naturally acquired giardiasis in dogs. ANIMALS: 6 male and 9 female Beagles. PROCEDURE: Dogs were identified as naturally infected with Giardia sp, using the zinc sulfate concentration technique (ZSCT), and were allocated to 1 of 3 groups. Group-1 dogs were treated orally with a praziquantel (5.4 to 7 mg/kg of body weight), pyrantel pamoate (26.8 to 35.2 mg/kg), and febantel (26.8 to 35.2 mg/kg) combination, every 24 hours for 3 doses. Group-2 dogs were treated with the combination once. Group-3 dogs were nontreated controls. Four fecal samples were examined, using the ZSCT, from each dog of each group within 6 days of the last treatment. Dogs were considered to have giardiasis if 1 or more of the fecal samples had positive results for Giardia cysts. Dogs were examined daily for at least 10 days after the last treatment. RESULTS:Giardia cysts were not detected in the feces of any group-1 dog or in the feces of 2 of 5 group-2 dogs. Cysts were detected in the feces of 5 of 5 group-3 (nontreated control) dogs. Signs of toxicosis were not observed in any dog. CONCLUSION AND CLINICAL RELEVANCE: The current labeled dose (for treatment of various nematodes and cestodes, but not Giardia sp) of the combination given orally once reduces cyst excretion in Giardia-infecteddogs, and should be considered for treatment of dogs shedding Giardia cysts, whether or not they have clinical signs of infection.
Authors: Kirsten A Anderson; Andrew S Brooks; Annette L Morrison; Richard J Reid-Smith; S Wayne Martin; Denna M Benn; Andrew S Peregrine Journal: Can Vet J Date: 2004-11 Impact factor: 1.008
Authors: Pramod N Nehete; Gregory Wilkerson; Bharti P Nehete; Sriram Chitta; Julio C Ruiz; Henrieta Scholtzova; Lawrence E Williams; Christian R Abee; John A Vanchiere Journal: PLoS One Date: 2018-11-09 Impact factor: 3.240
Authors: Lavinia Ciuca; Paola Pepe; Antonio Bosco; Simone Mario Caccio; Maria Paola Maurelli; Anna Rosa Sannella; Alice Vismarra; Giuseppe Cringoli; Laura Kramer; Laura Rinaldi; Marco Genchi Journal: Front Vet Sci Date: 2021-03-26