Literature DB >> 9735354

Lhx2, a vertebrate homologue of apterous, regulates vertebrate limb outgrowth.

C Rodriguez-Esteban1, J W Schwabe, J D Peña, D E Rincon-Limas, J Magallón, J Botas, J C Izpisúa Belmonte.   

Abstract

apterous specifies dorsal cell fate and directs outgrowth of the wing during Drosophila wing development. Here we show that, in vertebrates, these functions appear to be performed by two separate proteins. Lmx-1 is necessary and sufficient to specify dorsal identity and Lhx2 regulates limb outgrowth. Our results suggest that Lhx2 is closer to apterous than Lmx-1, yet, in vertebrates, Lhx2 does not specify dorsal cell fate. This implies that in vertebrates, unlike Drosophila, limb outgrowth can be dissociated from the establishment of the dorsoventral axis.

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Year:  1998        PMID： 9735354     DOI： 10.1242/dev.125.20.3925

Source DB:  PubMed          Journal:  Development        ISSN： 0950-1991            Impact factor:   6.868


  17 in total

1.  Fgfr2 is required for limb outgrowth and lung-branching morphogenesis.

Authors:  E Arman; R Haffner-Krausz; M Gorivodsky; P Lonai
Journal:  Proc Natl Acad Sci U S A       Date:  1999-10-12       Impact factor: 11.205

2.  The level of DLDB/CHIP controls the activity of the LIM homeodomain protein apterous: evidence for a functional tetramer complex in vivo.

Authors:  D E Rincón-Limas; C H Lu; I Canal; J Botas
Journal:  EMBO J       Date:  2000-06-01       Impact factor: 11.598

3.  Dual role for Drosophila epidermal growth factor receptor signaling in early wing disc development.

Authors:  S H Wang; A Simcox; G Campbell
Journal:  Genes Dev       Date:  2000-09-15       Impact factor: 11.361

4.  Architectural niche organization by LHX2 is linked to hair follicle stem cell function.

Authors:  Alicia R Folgueras; Xingyi Guo; H Amalia Pasolli; Nicole Stokes; Lisa Polak; Deyou Zheng; Elaine Fuchs
Journal:  Cell Stem Cell       Date:  2013-09-05       Impact factor: 24.633

5.  Opposing Fgf and Bmp activities regulate the specification of olfactory sensory and respiratory epithelial cell fates.

Authors:  Esther Maier; Jonas von Hofsten; Hanna Nord; Marie Fernandes; Hunki Paek; Jean M Hébert; Lena Gunhaga
Journal:  Development       Date:  2010-04-14       Impact factor: 6.868

6.  Conservation of the expression and function of apterous orthologs in Drosophila and mammals.

Authors:  D E Rincón-Limas; C H Lu; I Canal; M Calleja; C Rodríguez-Esteban; J C Izpisúa-Belmonte; J Botas
Journal:  Proc Natl Acad Sci U S A       Date:  1999-03-02       Impact factor: 11.205

Review 7.  LIM-homeodomain genes in mammalian development and human disease.

Authors:  Chad S Hunter; Simon J Rhodes
Journal:  Mol Biol Rep       Date:  2005-06       Impact factor: 2.316

8.  Hedgehog pathway activation and epithelial-to-mesenchymal transitions during myofibroblastic transformation of rat hepatic cells in culture and cirrhosis.

Authors:  Steve S Choi; Alessia Omenetti; Rafal P Witek; Cynthia A Moylan; Wing-Kin Syn; Youngmi Jung; Liu Yang; Debra L Sudan; Jason K Sicklick; Gregory A Michelotti; Marcos Rojkind; Anna Mae Diehl
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2009-10-08       Impact factor: 4.052

9.  LIM homeobox transcription factors integrate signaling events that control three-dimensional limb patterning and growth.

Authors:  Itai Tzchori; Timothy F Day; Peter J Carolan; Yangu Zhao; Christopher A Wassif; Liqi Li; Mark Lewandoski; Marat Gorivodsky; Paul E Love; Forbes D Porter; Heiner Westphal; Yingzi Yang
Journal:  Development       Date:  2009-04       Impact factor: 6.868

10.  Expression of the Lhx genes apterous and lim1 in an errant polychaete: implications for bilaterian appendage evolution, neural development, and muscle diversification.

Authors:  Christopher J Winchell; David K Jacobs
Journal:  Evodevo       Date:  2013-02-01       Impact factor: 2.250
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