| Literature DB >> 9734394 |
M P Piccinni1, L Beloni, C Livi, E Maggi, G Scarselli, S Romagnani.
Abstract
Leukemia inhibitory factor is essential for embryo implantation, and a shift from type 1 T-helper to type 2 T-helper response at the fetal-maternal interface may contribute to successful pregnancy. We show that LIF production is associated with type 2 T-helper cells, is upregulated by IL-4 and progesterone and is downregulated by IL-12, IFN-gamma and IFN-alpha. We also show a decreased production of LIF, IL-4 and IL-10 by decidual T cells of women with unexplained recurrent abortions in comparison with that of women with normal gestation. The defective production of LIF and/or type 2 T-helper cytokines may contribute to the development of unexplained recurrent abortions.Entities:
Mesh：
Substances：
Year: 1998 PMID： 9734394 DOI： 10.1038/2006
Source DB: PubMed Journal: Nat Med ISSN： 1078-8956 Impact factor: 53.440