Literature DB >> 9734318

Kotalanol, a potent alpha-glucosidase inhibitor with thiosugar sulfonium sulfate structure, from antidiabetic ayurvedic medicine Salacia reticulata.

M Yoshikawa1, T Murakami, K Yashiro, H Matsuda.   

Abstract

A potent natural alpha-glucosidase inhibitor called kotalanol has been isolated from an antidiabetic traditional Ayurvedic medicine, the roots and stems of Salacia reticulata Wight, through bioassay-guided separation. The structure of kotalanol was elucidated on the basis of chemical and physicochemical evidence to be the inner salt comprised of 1-deoxyheptosyl-3-sulfate anion and 1-deoxy-4-thio-D-arabinofuranosyl sulfonium cation. Kotalanol was found to show more potent inhibitory activity against sucrase than salacinol and acarbose.

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Year:  1998        PMID： 9734318     DOI： 10.1248/cpb.46.1339

Source DB:  PubMed          Journal:  Chem Pharm Bull (Tokyo)        ISSN： 0009-2363            Impact factor:   1.645


  26 in total

1.  A biosynthetic pathway for BE-7585A, a 2-thiosugar-containing angucycline-type natural product.

Authors:  Eita Sasaki; Yasushi Ogasawara; Hung-Wen Liu
Journal:  J Am Chem Soc       Date:  2010-06-02       Impact factor: 15.419

Review 2.  Antidiabetic Potential of Medicinal Plants and Their Active Components.

Authors:  Bahare Salehi; Athar Ata; Nanjangud V Anil Kumar; Farukh Sharopov; Karina Ramírez-Alarcón; Ana Ruiz-Ortega; Seyed Abdulmajid Ayatollahi; Patrick Valere Tsouh Fokou; Farzad Kobarfard; Zainul Amiruddin Zakaria; Marcello Iriti; Yasaman Taheri; Miquel Martorell; Antoni Sureda; William N Setzer; Alessandra Durazzo; Massimo Lucarini; Antonello Santini; Raffaele Capasso; Elise Adrian Ostrander; Muhammad Iqbal Choudhary; William C Cho; Javad Sharifi-Rad
Journal:  Biomolecules       Date:  2019-09-30

3.  Quantitative analysis of neosalacinol and neokotalanol, another two potent α-glucosidase inhibitors from Salacia species, by LC-MS with ion pair chromatography.

Authors:  Osamu Muraoka; Toshio Morikawa; Sohachiro Miyake; Junji Akaki; Kiyofumi Ninomiya; Yutana Pongpiriyadacha; Masayuki Yoshikawa
Journal:  J Nat Med       Date:  2010-10-28       Impact factor: 2.343

Review 4.  The biosynthesis of nitrogen-, sulfur-, and high-carbon chain-containing sugars.

Authors:  Chia-I Lin; Reid M McCarty; Hung-wen Liu
Journal:  Chem Soc Rev       Date:  2013-01-25       Impact factor: 54.564

5.  The structure and conformational behavior of sulfonium salt glycosidase inhibitors in solution: a combined quantum mechanical NMR approach.

Authors:  Jorge Gonzalez-Outeiriño; John Glushka; Aloysius Siriwardena; Robert J Woods
Journal:  J Am Chem Soc       Date:  2004-06-09       Impact factor: 15.419

6.  Salacia reticulata has therapeutic effects on obesity.

Authors:  Tsutomu Shimada; Yuichiro Nakayama; Yukiko Harasawa; Hirofumi Matsui; Hiroko Kobayashi; Yoshimichi Sai; Ken-ichi Miyamoto; Shunji Tomatsu; Masaki Aburada
Journal:  J Nat Med       Date:  2014-05-18       Impact factor: 2.343

7.  Effects of the Sri Lankan medicinal plant, Salacia reticulata, in rheumatoid arthritis.

Authors:  Yuusuke Sekiguchi; Hiroshi Mano; Sachie Nakatani; Jun Shimizu; Masahiro Wada
Journal:  Genes Nutr       Date:  2009-09-02       Impact factor: 5.523

8.  Anti-proliferative effects of Salacia reticulata leaves hot-water extract on interleukin-1β-activated cells derived from the synovium of rheumatoid arthritis model mice.

Authors:  Yuusuke Sekiguchi; Hiroshi Mano; Sachie Nakatani; Jun Shimizu; Kenji Kobata; Masahiro Wada
Journal:  BMC Res Notes       Date:  2012-04-26

9.  The role of lipid and carbohydrate digestive enzyme inhibitors in the management of obesity: a review of current and emerging therapeutic agents.

Authors:  Sonia A Tucci; Emma J Boyland; Jason Cg Halford
Journal:  Diabetes Metab Syndr Obes       Date:  2010-05-10       Impact factor: 3.168

10.  Preventive Effects of Salacia reticulata on Obesity and Metabolic Disorders in TSOD Mice.

Authors:  Tomoko Akase; Tsutomu Shimada; Yukiko Harasawa; Tomohide Akase; Yukinobu Ikeya; Eiichi Nagai; Seiichi Iizuka; Gojiro Nakagami; Shinji Iizaka; Hiromi Sanada; Masaki Aburada
Journal:  Evid Based Complement Alternat Med       Date:  2011-06-23       Impact factor: 2.629
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