Literature DB >> 9733889

1,25-Dihydroxyvitamin D3 upregulates functional CXCR4 human immunodeficiency virus type 1 coreceptors in U937 minus clones: NF-kappaB-independent enhancement of viral replication.

P Biswas1, M Mengozzi, B Mantelli, F Delfanti, A Brambilla, E Vicenzi, G Poli.   

Abstract

U937 cell clones which sustain efficient or poor replication of human immunodeficiency virus type 1 (HIV-1) (referred to herein as plus clones and minus clones, respectively) have been previously described. 1,25-Dihydroxyvitamin D3 (vitamin D3) potently induced HIV-1 replication and proviral DNA accumulation in minus clones but not in plus clones. Vitamin D3 did not induce NF-kappaB activation but selectively upregulated CXCR4 expression in minus clones. The CXCR4 ligand stromal-cell derived factor-1 induced Ca2+ fluxes and inhibited both constitutive and vitamin D3-enhanced HIV replication in minus clones.

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Year:  1998        PMID： 9733889      PMCID： PMC110220     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  37 in total

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Journal:  Nature       Date:  1996-08-29       Impact factor: 49.962

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2.  Envelope-dependent restriction of human immunodeficiency virus type 1 spreading in CD4(+) T lymphocytes: R5 but not X4 viruses replicate in the absence of T-cell receptor restimulation.

Authors:  E Vicenzi; P P Bordignon; P Biswas; A Brambilla; C Bovolenta; M Cota; F Sinigaglia; G Poli
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5.  A Functional Bioluminescent Zebrafish Screen for Enhancing Hematopoietic Cell Homing.

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Review 6.  Vitamin D in Human Immunodeficiency Virus Infection: Influence on Immunity and Disease.

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7.  Vitamin D treatment of peripheral blood mononuclear cells modulated immune activation and reduced susceptibility to HIV-1 infection of CD4+ T lymphocytes.

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8.  Functional Studies of CCAAT/Enhancer Binding Protein Site Located Downstream of the Transcriptional Start Site.

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  8 in total

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