O Farges1, J M Regimbeau, J Belghiti. 1. Department of Hepato-biliary and Digestive Surgery, Beaujon Hospital, University Paris VII, Clichy, France.
Abstract
BACKGROUND: Liver resection of hepatocellular carcinoma (HCC) is associated with a high incidence of recurrence, that has a poor prognosis. AIM: Assess the rationale for and result of an aggressive treatment of recurrence following resection of HCC. METHODOLOGY: Retrospective analysis of 132 patients with recurrent HCC with special reference to the topography and time of onset of recurrence as well as outcome following treatment of these recurrences. Case-control analysis of the efficacy of repeat hepatectomy and its influence on the long term prognosis of patients with recurrent tumor. RESULTS: Sixty seven percent of the recurrences were exclusively intrahepatic and half of these were limited in size and number. The 5-year survival rate following treatment of limited intrahepatic recurrence by repeat hepatectomy, arterial chemoembolization or percutaneous ethanol injection was 30%. Repeat hepatectomies improved the long term outcome of patients with recurrent HCC. CONCLUSION: An aggressive approach to tumor recurrence is currently the best way to improve the long term outcome following resection of HCC.
BACKGROUND: Liver resection of hepatocellular carcinoma (HCC) is associated with a high incidence of recurrence, that has a poor prognosis. AIM: Assess the rationale for and result of an aggressive treatment of recurrence following resection of HCC. METHODOLOGY: Retrospective analysis of 132 patients with recurrent HCC with special reference to the topography and time of onset of recurrence as well as outcome following treatment of these recurrences. Case-control analysis of the efficacy of repeat hepatectomy and its influence on the long term prognosis of patients with recurrent tumor. RESULTS: Sixty seven percent of the recurrences were exclusively intrahepatic and half of these were limited in size and number. The 5-year survival rate following treatment of limited intrahepatic recurrence by repeat hepatectomy, arterial chemoembolization or percutaneous ethanol injection was 30%. Repeat hepatectomies improved the long term outcome of patients with recurrent HCC. CONCLUSION: An aggressive approach to tumor recurrence is currently the best way to improve the long term outcome following resection of HCC.
Authors: Victor Zaydfudim; Rory L Smoot; Clancy J Clark; Michael L Kendrick; Florencia G Que; Michael B Farnell; David M Nagorney Journal: J Gastrointest Surg Date: 2012-05-30 Impact factor: 3.452
Authors: Richard Bell; Sanjay Pandanaboyana; J Peter A Lodge; K Raj Prasad; Rebecca Jones; Ernest Hidalgo Journal: Langenbecks Arch Surg Date: 2016-07-25 Impact factor: 3.445