| Literature DB >> 9730246 |
N Ohtake1, H Imamura, H Jona, H Kiyonaga, A Shimizu, M Moriya, H Sato, M Nakano, R Ushijima, S Nakagawa.
Abstract
A new series of 1beta-methyl carbapenems, in which a disubstituted-aminothiocarbonylthio moiety was attached to the C-2 position of the carbapenem nucleus, were prepared and evaluated for anti-MRSA activity. These derivatives showed good in vitro antibacterial activity against high-level MRSA, and the finding of good affinity for PBP-2' supported these results. Some of the compounds having favorable protein-binding affinity showed excellent in vivo anti-MRSA activity.Entities:
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Year: 1998 PMID： 9730246 DOI： 10.1016/s0968-0896(98)00069-8
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641