Literature DB >> 9730224

Combinatorial synthesis and screening of a chemical library of 1,4-dihydropyridine calcium channel blockers.

M F Gordeev1, D V Patel, B P England, S Jonnalagadda, J D Combs, E M Gordon.   

Abstract

Solid-phase synthesis of a 300-member pharmacophore library of 1,4-dihydropyridines from keto ester, diketone and aldehyde building blocks on a cleavable amine polymeric support is described. Screening and serial deconvolution of the combinatorial library has resulted in identification of known and new potent calcium channel blockers.

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Year:  1998        PMID： 9730224     DOI： 10.1016/s0968-0896(98)00048-0

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  4 in total

1.  Synthesis and evaluation of 1,4-dihydropyridine derivatives with calcium channel blocking activity.

Authors:  Chris Bladen; Miyase Gözde Gündüz; Rahime Şimşek; Cihat Şafak; Gerald W Zamponi
Journal:  Pflugers Arch       Date:  2013-10-23       Impact factor: 3.657

2.  Ethyl 2,7,7-trimethyl-4-(1-methyl-1H-indol-3-yl)-5-oxo-1,4,5,6,7,8-hexa-hydro-quinoline-3-carboxyl-ate.

Authors:  Sema Oztürk Yildirim; Ray J Butcher; Miyase Gözde Gündüz; Ahmed El-Khouly; Rahime Simşek; Cihat Safak
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2012-12-08

3.  Ethyl 4-(5-bromo-1H-indol-3-yl)-2,6,6-trimethyl-5-oxo-1,4,5,6,7,8-hexa-hydro-quinoline-3-carboxyl-ate.

Authors:  Miyase Gözde Gündüz; Ray J Butcher; Sema Oztürk Yildirim; Ahmed El-Khouly; Cihat Safak; Rahime Simşek
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2012-11-24

4.  Enantioselective N-heterocyclic carbene-catalyzed nucleophilic dearomatization of alkyl pyridiniums.

Authors:  Darrin M Flanigan; Tomislav Rovis
Journal:  Chem Sci       Date:  2017-08-03       Impact factor: 9.825
  4 in total

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