Congenital candidiasis: varied presentations.

Congenital candidiasis, especially the disseminated disease, is very uncommon but has been reported in very low birth weight infants. Five cases of congenital candidiasis, two with cutaneous type and three with systemic type, are described. All cases were symptomatic within the first 24 hours of life and none of them had significant risk factors such as the presence of foreign body in the maternal genital tract. Cutaneous candidiasis presented as extensive erythematous rash with infiltrative plaques in one and as bullous lesions in the other. Three infants who had disseminated candidiasis presented with extreme leukemoid reaction, severe hyperglycemia, and skin mottling with some patchy areas resembling first-degree burns, respectively. One infant had meningitis and the autopsy of another who died revealed several microabscesses containing Candida spores in the liver and lungs. The urine microscopy obtained by suprapubic bladder aspiration was found to be a good diagnostic marker of systemic invasion. The purpose of this report is to highlight the importance of recognizing candida as a possible pathogen in a critically ill neonate even though the clinical presentation may be nonspecific and varied. The presence of characteristic skin lesions of Candida species within 24 hours of life is an important clue to the possible diagnosis of congenital candidal infection. Even though very high mortality has been reported in congenital disseminated candidiasis, early recognition and treatment could give a favorable outcome.