Literature DB >> 97289

Regulation of the rate of beta-galactosidase synthese by the Bgs and Bgt loci in the mouse.

F G Berger, K Paigen.   

Abstract

We have developed an assay for the in vivo rate of beta-galactosidase synthesis in mouse tissues to assess the mechanism by which the Bgs and Bgt loci regulate activity levels of this enzyme. Genetically determined differences in liver and kidney beta-galactosidase content reflect equivalent differences in specific rates of enzyme synthesis. We conclude that Bgs and Bgt regulate beta-galactosidase activity by controlling the rate of synthesis of the beta-galactosidase molecule.

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Year:  1978        PMID： 97289

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  10 in total

1.  Relationship between genetic variation in thermal stability and electrophoretic mobility of mouse beta-galactosidase.

Authors:  F G Berger; A J Lusis
Journal:  Biochem Genet       Date:  1978-10       Impact factor: 1.890

2.  Genetic control of developmental patterns of cerebral enzyme activities: further differences between C3H and ICR strains of mice.

Authors:  T D Bird; D F Farrell; S Stranahan
Journal:  Neurochem Res       Date:  1981-08       Impact factor: 3.996

3.  Substrate specificity and distribution of acid beta-galactosidase activities in seizure-susceptible and non-susceptible strains of mice.

Authors:  D F Wheeler; H S Bachelard
Journal:  Neurochem Res       Date:  1984-06       Impact factor: 3.996

4.  Biosynthesis of the major urinary proteins in mouse liver: a biochemical genetic study.

Authors:  F G Berger; P Szoka
Journal:  Biochem Genet       Date:  1981-12       Impact factor: 1.890

5.  A gene affecting liver activities of three glycosidases in the house mouse.

Authors:  E M Håkansson; J Hilgers; L G Lundin
Journal:  Biochem Genet       Date:  1981-06       Impact factor: 1.890

6.  Genetically controlled variation of "acid" beta-galactosidase detected in Rattus norvegicus by isoelectric focusing.

Authors:  T C Douglas; K A Kimmel; P E Dawson
Journal:  Genetics       Date:  1982-03       Impact factor: 4.562

7.  A gene (Bmn) controlling beta-mannosidase activity in the mouse is located in the distal part of chromosome 3.

Authors:  L G Lundin
Journal:  Biochem Genet       Date:  1987-08       Impact factor: 1.890

8.  A cis-active regulatory gene in the mouse: direct demonstration of cis-active control of the rate of enzyme subunit synthesis.

Authors:  E G Bernstine; C Koh
Journal:  Proc Natl Acad Sci U S A       Date:  1980-07       Impact factor: 11.205

9.  Arylsulfatase B synthesis and clearance in inbred mouse strains.

Authors:  W L Daniel
Journal:  Experientia       Date:  1987-12-01

10.  Rat epididymal luminal fluid acid beta-D-galactosidase optimally hydrolyses glycoprotein substrate at neutral pH.

Authors:  M D Skudlarek; D R Tulsiani; M C Orgebin-Crist
Journal:  Biochem J       Date:  1992-09-15       Impact factor: 3.857
  10 in total

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